摘要
目的建立并探讨汉中地区正常孕妇不同孕期的甲状腺功能测量结果正常参考值范围。方法收集2012年7月~2015年12月汉中地区常住妊娠妇女4 031例,按NACB纳入标准,采用随机、分层、整群抽样相结合的方法,使用全自动化学发光分析仪及其配套试剂进行甲状腺激素水平检测,并据不同孕期分为:早孕(T1)998例,中孕(T2)1 543,晚孕(T3)1 490例,同时选取年龄相仿的未妊娠育龄期妇女(T0)105例作为对照组。结果①妊娠三期甲状腺激素水平不同,TSH于早、中、晚三期分别为0.25~5.32,0.42~6.26和0.61~7.68 mIU/L;FT3分别为3.54~6.04,3.57~5.94和2.93~5.40 pmol/L;FT4分别为7.11~16.88,6.78~16.94和6.03~16.87 pmol/L,妊娠期妇女的甲状腺激素水平与未孕妇女相比较,TSH(X^2=233.183,P<0.05),FT4(X^2=388.12,P<0.05),FT3(X^2=558.795,P<0.05))。②TSH在孕早期相对于未孕妇女减低,孕中晚期相对增高;FT3和FT4的变化是一致的,与非孕妇女相比均是减低的,且随孕期延长下降越明显。结论妊娠妇女甲状腺功能水平不同于非孕妇女,需建立当地妊娠特异性甲状腺激素正常参考范围。
Objective To establish the reference range of thyroid function from the normal pregnant women in different preg nant period in Hanzhong region. Methods According to the NACB inclusion criteria, collected local resident pregnant women 4 031 cases, from July 2012 to December 2015. With the combination of random sampling, stratified sampling and cluster sampling, thyroid hormone levels were measured by a fully automated chemiluminescence analyzer and its accompanying reagents. All patients were divided into three groups..998 cases in early pregnancy （T1）, 1 543 cases in mid pregnancy （T2） ,1 490 cases in late pregnancy （T3）,and 105 cases of non-pregnant women in childbearing age （TO） were selected as control group. Results The levels of thyroid hormones were different among three periods of pregnant women. TSH were 0. 25-5. 32,0. 42-6. 26 and 0.61-7.68 mlU/L respectively in the early,middle and late stages. FT3 were 3.54-6.04, 3.57-5.94 and 2.93-5.40 pmol/L,respectively. FT4 was 7. 11-16. 88 , 6. 78-16. 94 and 6.03-16.87 pmol/L. Thyroid hormone levels in pregnant women compared with non-pregnant women, there were significant differences （TSH： X^2=233. 183,P〈0.05,FT4：X^2=388.12,P〈0.05 and FT3：X^2=558. 795,P〈0.05）. TSH were lower in early pregnant women comparing to non pregnancy women,and higher in middle-late pregnant women. The change of FT3 and FT4 were consistent,and reduced with the extension of pregnancy comparing to non-pregnancy women. Conclusion The level of thyroid function in pregnant women were different from non-pregnant women, and the normal reference range of local pregnant specific thyroid hormone should be established.
出处
《现代检验医学杂志》
CAS
2017年第3期144-145,148,共3页
Journal of Modern Laboratory Medicine
关键词
妊娠
甲状腺激素
正常参考范围
pregnancy
thyroid hormone
the normal reference range
