摘要
高迁移率族蛋白B1(high mobility group box 1 protein,HMGB1)是核内一类非组蛋白DNA结合蛋白,属于损伤相关分子模式(damage-associated molecular patterns,DAMPs),参与DNA复制、重组、修复和基因转录调控等。HMGB1能通过Toll样受体(Toll-like receptor,TLR)等激活固有免疫以及诱导T细胞分化成熟启动适应性免疫应答,与多种自身免疫性疾病、炎症性疾病和肿瘤等关系密切。目前关于HMGB1介导TLR信号通路在某些疾病中的作用的研究较多,HMGB1介导Toll样受体信号通路参与多种病理过程具有广阔的临床前景。
High mobility group box 1 protein,a kind of damage-associated molecular patterns,is a group of nonhistone DNA- binding protein in the nuclear. It not only involves in DNA replication, recombination, repair, regulation of gene transcription,but also induces activation of innate immunity and T cell generation and activates the adaptive immune response through Toll-like receptor. It is also more closely related to autoimmune diseases,inflammatory diseases, tumors and so on. Currently there are many researches on the role of TLR-mediated HMGB1 signaling pathway in diseases, which is involved in a variety of pathological processes and has a broad clinical outlook.
出处
《现代检验医学杂志》
CAS
2017年第3期162-164,共3页
Journal of Modern Laboratory Medicine
关键词
高迁移率蛋白B1
TOLL样受体
信号通路
high mobility group box 1 protein
toll-like receptor
signaling pathway
