摘要
目的观察自体角膜缘干细胞移植与羊膜移植治疗原发性翼状胬肉的临床疗效。方法选择翼状胬肉68例（75眼），按随机数字表分为两组：干细胞移植组35例（38眼）行胬肉切除联合自体角膜缘干细胞移植术；羊膜移植组33例（37眼）行胬肉切除联合羊膜移植术。观察两组术后复发情况、角膜创面愈合时间及并发症。结果干细胞移植组复发率2．6％，羊膜移植组复发率18．9％，干细胞移植组复发率低于羊膜移植组。干细胞移植组角膜创面愈合时间平均（3．49±0．50）d，羊膜移植组角膜创面愈合时间平均（5．28±1．37）d。干细胞移植组角膜创面愈合时间短于羊膜移植组，差异有统计学意义（t=7．550，P=0．000）。结论自体角膜缘干细胞移植治疗原发性翼状胬肉修复时间更短，复发及并发症更少，疗效优于羊膜移植。
Objective To observe the clinical effect of amniotic membrane transplantation and autologous corneal limbal stem cell transplantation in the treatment of primary pterygium. Methods Seventyfive eyes of 68 cases of pterygium were randomly divided into two groups： the stem cell transplantation groups, 38 eyes of 35 cases, underwent pterygium excision combined with autologous limbal stem cell transplantation; amniotic membrane transplantation group, 37 eyes of 33 cases, underwent pterygium excision combined with amniotic membrane transplantation. The postoperative recurrence, corneal wound healing time and complications of two groups were observed. Results The recurrence rate of stem cell transplantation group was 2.6%, the recurrence rate of amniotic membrane transplantation group was 18.9%, and the recurrence rate of stem cell transplantation group was lower than that of amniotic membrane transplantation group. In the stem ceil transplantation group, corneal wound healing time was average （3.49 ±0. 50） days, the average time of corneal wound healing time was （5.28 ±1.37 ） days. The corneal wound healing time of the stem cell transplantation group was shorter than that of the amniotic membrane transplantation group, the difference was statistically significant （ t = 7. 550, P = 0. 000 ）. Conclusion The effect of autologous corneal limbal stem cell transplantation for primary pterygium, with shorter healing time, lower recurrence rate and fewer complications, is better than that of amniotic membrane transplantation.
出处
《中华眼外伤职业眼病杂志》
2017年第6期460-462,共3页
Chinese Journal of Ocular Trauma and Occupational Eye Disease
关键词
翼状胬肉
移植
干细胞
羊膜
Pterygium
Transplantation
Stem cell
Amniotic membrane
