摘要
目的探讨TP方案新辅助化疗治疗局部晚期食管癌的疗效,为局部晚期食管癌的治疗提供可靠的依据。方法选取2014年1月~2016年3月在我院住院的局部晚期食管鳞癌患者34例进行研究,所有患者均采用TP方案新辅助化疗,每2周期化疗后评价疗效及不良反应,2~4个周期后行手术治疗,无法手术患者予行根治性放疗,观察患者治疗后的疗效及安全性。结果 34例患者经新辅助化疗后完全缓解3例,占8.82%,部分缓解15例,占44.12%;稳定15例,占44.12%,疾病进展1例,占2.94%,总有效率为52.94%。成功行根治性手术23例,占67.65%;治疗期间1级不良反应12例,占35.29%,2级8例,占23.53%,3级3例,占8.82%;4级1例,占2.94%;无5级不良反应。结论 TP方案新辅助化疗治疗局部晚期食管鳞癌可有效缩小肿瘤体积,提高手术切除率,不良反应轻,值得临床推广应用。
Objective To explore the efficacy of TP regimen adjuvant neoadjuvant chemotherapy in the treatment of locally advanced esophageal carcinoma,and to provide a reliable basis for the treatment of locally advanced esophageal cancer.Methods 34 patients with locally advanced esophageal squamous cell carcinoma who were hospitalized in our hospital from January 2014 to March 2016 were enrolled.All patients underwent neoadjuvant chemotherapy with TP regimen.The efficacy and adverse reaction were evaluated every 2 cycles.2-4 cycles after surgery,surgery can not be given for radical radiotherapy patients,and efficacy and safety of patients after treatment in patients were observed.Results Among 34 patients,3 cases were complete remission after neoadjuvant chemotherapy,accounting for 8.82%,15 cases of partial remission,accounting for 44.12%;stable 15 cases,accounting for 44.12%,1 case of disease,accounting for 2.94%.The total efficiency rate was 52.94%.23 cases（67.65%） were treated with radical resection,accounting for 12 cases（35.29%）,8 cases（grade 2,23.53%）,3 cases（grade 3,8.82%）,1 case（grade 4,2.94%） and it had no grade 5 of adverse reaction.Conclusion The neoadjuvant chemotherapy of TP regimen can effectively reduce the tumor volume,improve the resection rate and mild adverse reaction in the treatment of locally advanced esophageal squamous cell carcinoma.It is worthy of clinical promotion and application.
作者
王晓芬
吴珊珊
蔡艾芳
许宏伟
吴爱玲
林尤恩
WANG Xiao-fen WU Shan-shan CAI Ai-fang XU Hong-wei WU Ai-ling LIN You-en(Department of Internal Medicine-Oncology,Jieyang People＇s Hospital in Guangdong Province,Jieyang 522000,Chin)
出处
《中国当代医药》
2017年第17期57-59,共3页
China Modern Medicine
基金
广东省揭阳市科技计划项目(2014B010204018)
关键词
局部晚期食管癌
新辅助化疗
TP方案
Locally advanced esophageal cancer
Neoadjuvant chemotherapy
TP regimen
