摘要
近年来由于器官修复干细胞治疗技术的提出,使得不能自身修复的关节软骨成为研究热点之一,间充质干细胞对膝关节软骨修复已表现出明显的治疗优势。学者们临床上初步研究了不同来源的间充质干细胞膝关节软骨修复作用,并通过结合移植、软骨组织工程等技术提高了骨髓、脂肪、滑膜、脐带血等来源干细胞修复人类软骨效果,均取得了较好的临床疗效。不同干细胞来源不同各自会有一定的优缺点。目前临床研究仍处于试验阶段,尚无确切定论何种干细胞及何种技术处理最适合于人类软骨的修复。大规模和或结合新处理技术的临床试验以及远期疗效的验证,需要进一步临床深入研究。
As propose of organ repair stem cell therapy technology,articular cartilage cannot be repaired by itself has become one of the research hotspots,repair of articular cartilage with mesenchymal stem cells has shown obvious advantages for the treatment. The scholars have made a preliminary study on the role of mesenchymal stem cells from different sources in the repair of knee articular cartilage,and with the combination of transplantation and cartilage tissue engineering,these technologies improved the human cartilage repair effect of bone marrow,adipose,synovium,cord blood derived stem cells,which achieved good clinical curative effect. Due to the different sources,the dominant and recessive factors,each stem cell will have certain advantages and disadvantages. At present,the clinical research is still in the experimental stage,there is no definite conclusion on which kind of stem cell or technology is more suitable for human cartilage repair. This requires the validation of large scale or combining with new processing technology clinical trials and the long term clinical effect,it also provides for the basis for further clinical research.
作者
王连
侯鹏
蒋涛
汪宗保
赵银学
吴可
WANG Lian HOU Peng JIANG Tao WANG Zong-bao ZHA O Yin-xue WU Ke(Clinical School of Acupuncture and Orthopaedics ,Anhui University of Chinese Medicine ,Hefei 230038 ,A nhui, Chin)
出处
《中国骨伤》
CAS
2017年第6期581-586,共6页
China Journal of Orthopaedics and Traumatology
关键词
干细胞
膝关节
软骨
修复外科手术
Stem cells
Knee joint
Cartilage
Reconstructive surgical procedures
