摘要
目的探讨血清视黄醇结合蛋白(RBP)、超敏C反应蛋白(hs-CRP)与糖尿病足的相关性。方法选择收治的2型糖尿病患者189例,将其分为糖尿病足组105例、糖尿病组84例,并选择50例健康人作为对照组,比较3组受试者各临床指标,并比较不同分级糖尿病足患者RBP、hs-CRP水平。结果糖尿病组患者空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、肌酐(Cr)、尿酸(UA)、RBP、hs-CRP水平明显高于对照组(P<0.05),而糖尿病足组患者FBG、HbA1c、HOMAIR、Cr、UA、RBP、hs-CRP水平明显高于对照组和糖尿病组(P<0.05);对于糖尿病足患者,Wagner分级Ⅱ~Ⅲ级患者血清RBP、hs-CRP、HOMA-IR水平明显高于Ⅰ级(P<0.05),而Ⅳ~Ⅴ级患者血清RBP、hs-CRP、HOMA-IR水平明显高于Ⅰ级、Ⅱ~Ⅲ级(P<0.05),各级Wagner分级患者FBG水平差异无统计学意义(P>0.05);糖尿病组患者血清RBP、hs-CRP水平与患者FBG、HbA1c、HOMA-IR、Cr、UA呈正相关关系(P<0.05)。结论血清RBP、hs-CRP水平在糖尿病足患者中出现明显升高,且与患者糖尿病足分级明显相关,对患者的病情评估具有一定的临床价值。
Objective To investigate the correlation between serum retinol binding protein（RBP）and high sensitive C reactive protein（hs-CRP）with diabetic foot.Methods One hundred and eighty-nine patients with type 2diabetes mellitus（T2DM）in our hospital were selected and divided into the diabetic foot group（105 cases）and diabetes mellitus group（84 cases）.Fifty healthy subjects were selected as the control group.The clinical indexes were compared among the three groups and the RBP and hs-CRP levels were also compared among different grades of diabetic foot.Results The levels of FBG,HbA1c,HOMA-IR,Cr,UA,RBP and hsCRP in the diabetic group were significantly higher than those in the control group（P〈0.05）,which in patients with the diabetic foot were significantly higher than those in the control group and diabetes mellitus group（P〈0.05）;in the patients with diabetic foot,the levels of FBG,HOMA-IR,Cr,UA,RBP and were significantly higher than those in the control group and diabetic group（P〈0.05）.For the patients with diabetic foot,the levels of serum RBP,hs-CRP and HOMA-IR in the patients with Wagner gradeⅡ-Ⅲ were significantly higher than those in the patients with Wagner grade Ⅰ（P〈0.05）,the levels of serum RBP,hs-CRP,HOMA-IR in the patients with Wagner gradeⅣ-Ⅴ were significantly higher than those in the patients with Wagner grade Ⅰ,Ⅱ-Ⅲ（P〈0.05）,but the FBG level had no statistical difference among various Wagner grades（P〈0.05）;in the diabetes mellitus group,serum RBP and hs-CRP levels had significantly positive correlation with the levels of FBG,HbA1 c,HOMA-IR,Cr and UA（P〈0.05）.Conclusion Serum RBP and hs-CRP levels in the patients with diabetic foot are significantly increased,moreover which have significant correlation with the diabetic foot grade and a certain value for evaluating the disease condition.
出处
《检验医学与临床》
CAS
2017年第12期1683-1685,共3页
Laboratory Medicine and Clinic
基金
国家高技术研究发展计划"863"计划总课题(2014AA022304)
关键词
视黄醇结合蛋白
超敏C反应蛋白
糖尿病足
retinol binding protein
high sensitive C reactive protein
diabetic foot
