摘要
目的:观察固脑益智汤联合多奈哌齐治疗老年肾虚痰浊型血管性痴呆(vascular dementia,VD)的临床疗效及其对血清中脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)和血管内皮生长因子(vascular endothelial growth factor,VEGF)水平的影响。方法:将102例VD随机分为观察组和对照组,每组51例。对照组给予常规措施和口服多奈哌齐片,每次5 mg,1次·d-1。观察组在对照组治疗基础上给予固脑益智汤,每天1剂,常规水煮,早晚温服。两组患者连续治疗3个月。比较两组中医证候相关症状评分、痴呆严重程度评分和临床疗效,检测两组患者血清中BDNF和VEGF水平。结果:治疗后,观察组患者证候相关症状评分和日常生活能力评分显著低于对照组,修订Folstein简易精神状态检查评分高于对照组(P<0.01)。观察组有效率为86.27%,对照组为68.63%,两组有效率比较,差异有统计学意义(P<0.05)。观察组治疗后血清中BDNF和VEGF水平显著高于对照组,差异有统计学意义(P<0.01)。结论:固脑益智汤联合多奈哌齐治疗老年肾虚痰浊型VD疗效显著,且可上调患者血清中BDNF和VEGF水平。
Objective：To observe the effect of Gunao Yizhi Tang combined with donepezil in treating vascular dementia（ VD） in elderly patients with syndrome of kidney deficiency and phlegm turbidity and its influence on serum levels of brain derived neurotrophic factor（ BDNF） and vascular endothelial growth factor（ VEGF）. Methods：102 VD cases were randomly divided into the control group（51 cases） and the treatment group（51 cases）. The control group was given routine therapy and donepezil. Based on control group,the treatment group was treated with Gunao Yizhi Tang,one dose a day and administered warm in the morning and evening. Continuous treatment for 3 months in the two groups. Scores of symptoms of traditional Chinese medicine（ TCM） and serious degree of VD and efficacy were compared in both groups. Serum levels of BDNF and VEGF were detected in both groups. Results：After treatment,scores of TCM and ADL of treatment group were obviously lower,while MMSE score was higher than control group（ P〈0. 01）. The effective rate of treatment group was 86. 27% superior to control group 68. 63%（ P〈0. 05）. After treatment,serum levels of BDNF and VEGF were remarkably higher than control group（ P〈0. 01）. Conclusion： Efficacy of Gunao Yizhi Tang combined with donepezil in treating VD with syndrome of kidney deficiency and phlegm turbidity is obvious,and increase serum levels of BDNF and VEGF.
出处
《中医学报》
CAS
2017年第6期1008-1010,1014,共4页
Acta Chinese Medicine
基金
河南省科技攻关计划项目(0624410033)
关键词
固脑益智汤
血管性痴呆
多奈哌齐
肾虚痰浊证
Gunao Yizhi Tang
vascular dementia
donepezil
syndrome of kidney deficiency and phlegm turbidity
