摘要
目的分析吡贝地尔与艾司西酞普兰联合用药对帕金森伴抑郁状态患者抑郁评分及神经症状康复的影响。方法选取2013~2016年来我院就诊的100例帕金森伴抑郁状态患者作为研究对象,50例作为对照组行吡贝地尔治疗,50例作为实验组行吡贝地尔联合艾司西酞普兰用药。用统一帕金森评分量表和汉密尔顿抑郁量表评估两组患者,分析其抑郁症状及神经症状康复情况。结果治疗14 d后,两组患者统一帕金森评分量表显著低于用药前(P均<0.05),组间比较无明显差异(P>0.05);对照组汉密尔顿抑郁量表评分与用药前无明显差异(P>0.05),而实验组评分明显降低(P<0.05)。治疗42d后,与用药前对比,两组统一帕金森评分量表和汉密尔顿抑郁量表评分均显著下降(P均<0.05),组间比较存在明显差异(P均<0.05)。结论吡贝地尔与艾司西酞普兰联合用药能够有效降低帕金森伴抑郁状态患者抑郁评分,有效缓解抑郁症状,同时促进神经症状康复。
Objective To analyze the effect of piribedil combined with escitalopram to the depression and neurological symptoms on patients with Parkinson disease and depressive disorder. Methods 100 cases of Parkinson disease with depression were seleeted in our hospital during 2013 - 2016 and divided into the control group （n=50） and the experiment group （n=50） . The patients in the control group were received piribedil, while the patients in the experiment group were piribedil and eseitalopram. Unified Parkinson＇ s disease rating scale and Hamilton depression scale were measured to analyze patients＇ depression and rehabilitation of neurological symptoms. Results After 14d of treatment, the score unified Parkinson＇ s disease rating seale of the two groups were signifieantly lower than that of before treatment （P both〈0.05 ）, but no significant difference between the two groups （P〉 0.05 ）; the score of Hamilton depression scale of the control group showed no significant difference between before and after treatment （ P〉 0.05 ）, while the score in the experiment group reduced significantly （P 〈 0.05 ） . After 42d of treatment, the scores of unified Parkinson＇ s disease rating seale and Hamilton depression scale in two groups were significantly decreased than those of before treatment （ P〈0.05 ） and there were obvious differences between the two groups （ P〈0.05 ） . Conclusion Piribedil combined with eseitalopram treatment ean effectively improve depression and promote the recovery of neurological symptoms in patients with Parkinson disease with depression.
出处
《国际精神病学杂志》
2017年第3期477-479,共3页
Journal Of International Psychiatry
