摘要
目的探讨艾司西酞普兰治疗稳定期慢性阻塞性肺疾病(s COPD)合并抑郁症的疗效及对患者心肺运动功能的影响。方法随机将78例s COPD合并抑郁症患者分为2组:对照组(n=39)予以常规治疗,观察组(n=39)在常规治疗基础上加用艾司西酞普兰。比较两组治疗前后汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、COPD疾病测试(CAT)评分、6min步行距离(6MWD)、静息肺功能及心肺运动试验(CPET)结果。结果治疗前,两组患者各项指标均无显著差异(P>0.05),且治疗6个月后两组患者上述指标均有了显著改善(P<0.05)。治疗后,观察组的HAMD、HAMA、CAT评分均显著低于对照组(P<0.05),6MWD、FEV1、FEV1%pred、FEV1/FVC及CPET结果均显著高于对照组(P<0.05)。结论艾司西酞普兰辅助治疗s COPD,能够减轻患者的焦虑、抑郁情绪,改善患者的心肺运动功能,值得在临床推广。
Objective To investigate the efficacy of escitalopram in the treatment of stable chronic obstructive pulmonary disease （ sCOPD ） accompanied with depression and its influence on the exercise cardio-pulmonary function. Methods 78 sCOPD patients with depression were randomly divided into two groups. The control group （n=39） were given conventional therapy, while the observation group （ n =39 ） were given escitalopram on the basis of the therapy given to the control group. The scores of Hamilton Depression Scale （ HAMD ） and Hamilton Anxiety Scale （ HAMA ）, the resuhs of COPD Disease Testing （ CAT ）, 6-minnute walking distance （ 6MWD ）, resting lung function and Cardiopulmonary Exercise Test （CPET） were all compared between the two groups. Results There was no significant differences between the two groups in all the test results （P〉 0.05）; after 6 months of treatment, significant improvement had been shown in both groups （P〈0.05） . After treatment, the scores of HAMD, HAMA and CAT of the observation group were significantly lower than those of the control group （P〈0.05）, and the improvement in 6MWD, FEV1, FEV1%pred, FEV1/FVC and CPET of the observation group were more significant than those of the control group （P 〈 0.05 ） . Conclusion Adjuvant therapy of Escitalopram can be more effective to relieve the emotions of anxiety and depression in sCOPD patients with depression and improve their exercise cardio-pulmonary function.
出处
《国际精神病学杂志》
2017年第3期499-502,共4页
Journal Of International Psychiatry
关键词
慢性阻塞性肺疾病
稳定期
抑郁症
艾司西酞普兰
心肺运动功能
Chronic obstructive pulmonary disease
Stable period
Depression
Escitalopram
Exercise cardiopulmonary function
