摘要
大柴胡汤对多个血脂指标均有不同程度改善,还可调节血液流变、改善血液黏稠度,提高高脂血症整体疗效,疗效确切、毒副作用小。动物实验、临床单用大柴胡汤或联合其他药物均可明显改善高脂血症血脂指标,包括降低胆固醇-TC、甘油三酯-TG、低密度脂蛋白-LDL、升高高密度脂蛋白-HDL;灌胃干预大柴胡汤可明显降低高脂血症模型大鼠TC、TG、LDL-C(P>0.05),并呈浓度依赖性关系;明显升高HDL。大柴胡汤对高脂血症引发的脑梗死、冠心病、急性胰腺炎、胆石症、胆囊炎、代谢综合征、脂肪肝、高尿酸血症等均有显著疗效。目前研究多局限于对高脂血症TC、TG、LDL-C、HDL-C几项指标影响,多为大柴胡汤加减临床应用,应用原方研究不足,缺乏药动学研究。期待把大柴胡汤整体效应与分子水平靶点结合,加强多因素对多靶点影响规律性研究,深层次揭示大柴胡汤干预作用实质;加强原方应用研究,提供循证医学证据,为以大柴胡汤原方做为基础方的新药研究奠定基础。
Dachaihu decoction improving on multiple lipid index in varying degrees, can also regulate blood rheology, improve blood viscosity, improve hyperlipidemia overall curative effect, curative effect, little side effect.Animal experiment and clinical use of Daehaihu decoction or in combination with other drugs can significantly improve blood lipids index,Including lowering cholesterol, -TC, triglyceride, -TG, low density lipoprotein -LDL, elevated high-density lipoprotein -HDL, intragastric intervention big Bupleurum decoction can significantly reduce hyperlipidemia rats model TC, TG, LDL-C （P〉0.05）,And in a concentration dependent manner.Dachaihmang lead to hyperlipidemia, coronary heart disease, cerebral infarction, acute panereatitis, eholecystitis, cholelithiasis, metabolic syndrome, fatty liver, hyperuricemia and other significant effeet.At present, the research is limited to the effects of several indexes such as TC, TG, LDL-C and HDL-C on hyperlipidemia.Mostly for the clinical application of large Bupleurum decoction, the use of the original side research deficiencies, the lack of pharmaeokinetic studies.Look forward to the overall effect of Dachaihu decoction and molecular level target combination, strengthen the regularity of influence of multi factors on multiple targets,reveal Daehaihutang intervention effect; strengthen the application research of the original, provide evidence of evidence-based medicine, to lay the foundation for the party to do research Dachaihu decoction basis of a new drug.
出处
《实用中医内科杂志》
2017年第6期86-89,共4页
Journal of Practical Traditional Chinese Internal Medicine
