摘要
目的:调查研究温州地区汉族人群MN血型表现型分布特点及其基因频率。方法:采用微孔板法对672名汉族无偿献血者样本进行MN血型抗原检测,如有可疑用盐水试管法确认,并统计其基因频率。结果:温州地区汉族人群MN血型分布特征为MN>M>N,基因频率为m>n(m=0.537 2、n=0.462 8),样本的观察值与期望值吻合较好(χ~2=0.027,P>0.05),符合Hardy-Weinberg平衡定律。结论:本次调查研究显示温州地区汉族人群的M基因频率高于N基因频率,掌握MN血型系统在温州地区汉族人群的表现型分布特点及其基因频率有利于建立相应的血源队伍,并对本地区的临床输血、新生儿同种免疫性疾病诊断、人类学研究等方面提供了理论依据。
Objective： To investigate the phenotype distribution characteristics of MN blood type as well as its gene frequency phenotype among Han population in Wenzhou. Method： A total of 672 blood samples were collect- ed from voluntary blood donors. MN blood group was detected by microplate method, then these suspicious MN blood group antigens were confirmed by test tube method, and gene frequency was calculated. Result.. MN blood type distribution characteristics of Han population in Wenzhou was MN〉M〉N with gene frequency of m〉n （m=0. 537 2, n=0. 462 8）; observed values of samples had good fitting with expected values. （X^2 =0. 027, P〈 0.05）, which conforms Hardy-Weinberg＇s equilibrium law. Conclusion.. The investigation showed that the frequen- cy of M gene in Wenzhou Han population was higher than the frequency of N gene. It would be beneficial to establish the corresponding blood-borne team by mastering phenotype distribution characteristics of MN blood type system as well as its gene frequency of Han population in Wenzhou, which could provide theoretical foundation for clinical blood transfusion locally, newborn homo-immune disease diagnosis and anthropological studies etc.
出处
《临床血液学杂志（输血与检验）》
CAS
2017年第3期447-449,共3页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
基金
浙江省温州市医药卫生科研基金资助项目(No:2013B37)
关键词
温州地区
汉族
MN血型
基因频率
Wenzhou
Han nationality
MN blood group
gene frequency
