摘要
目的分析返流性食管炎(RE)与精神因素的关联性。方法 102例返流性食管炎患者经过焦虑与抑郁评价系统评定后有78例患者评分异常,采取计算机随机分组方案分为常规组及实验组,每组39例。常规组给予奥美拉唑治疗,实验组在常规组基础上加用帕罗西汀治疗。对比两组治疗后心理症状评分、临床症状积分变化情况、药物不良反应。结果实验组患者的躯体化、强迫症状、焦虑、抑郁心理症状评分低于常规组,差异均具有统计学意义(P<0.05);两组患者的人际关系敏感、敌对、恐怖、偏执、精神病性心理症状评分比较,差异均无统计学意义(P>0.05)。实验组患者临床症状积分为(0.90±0.43)分,低于常规组的(1.23±0.42)分,差异具有统计学意义(P<0.05)。两组患者均未出现较为严重的药物不良反应。结论返流性食管炎与精神因素具有十分紧密的关联性,临床上应及时进行积极治疗,帮助患者提高治疗效果,缓解不良情绪。
Objective To analyze the correlation between reflux esophagitis （RE） and mental factor. Methods There were 78 patients with abnormal scores by evaluation system of anxiety and depression in 102 reflux esophagitis patients, and they were divided by computer random grouping scheme into conventional group and experimental group, with 39 cases in each group. The conventional group received omeprazole for treatment, and＇the experimental group also received paroxetine for treatment. Comparison were made on change of mental symptom scores and clinical symptoms integral, and adverse drug reactions after treatment in two groups. Results The experimental group had lower mental symptom scores of somatization, forced symptoms, anxiety, depression than the conventional group, and their difference had statistical significance （P〈O.05）. Both groups had no statistically significant difference in mental symptom scores of interpersonal sensitivity, hostility, terror, paranoia, psychosis （P〉0.05）. The experimental group had lower clinical symptom integral as （0.90 ± 0.43） points than （1.23 ± 0.42） points in the conventional group, and the difference had statistical significance （P〈O.05）. Both groups had no serious adverse drug reactions. Conclusion Reflux esophagitis and mental factors have very close correlation, active treatment should be performed in clinic to help patients improve the treatment effect and reduce bad feelings.
出处
《中国实用医药》
2017年第17期27-29,共3页
China Practical Medicine
关键词
精神因素
返流性食管炎
分析
Mental factor
Reflux esophagitis
Analysis
