摘要
目的分析血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、糖类抗原125(CA125)和糖类抗原242(CA242)联合检测对肺癌诊断准确率的影响。方法选取2015年6月至2016年12月间南通市肿瘤医院收治的102例肺癌患者作为研究组,选取同期医院经胸片或胸部CT诊断为肺良性疾病的102例患者作为对照组;对两组患者进行血清CEA、CYFRA21-1、NSE、CA125和CA242联合检测,比较两组患者五种血清肿瘤标志物指标变化。结果研究组患者血清CEA、CYFRA21-1、NSE、CA125和CA242水平均较对照组升高明显,差异均有统计学意义(均P<0.05)。研究组患者在疾病不同分期内血清CEA、CYFRA21-1、NSE、CA125和CA242水平变化显著(P<0.05)。联合检测血清CEA、CYFRA21-1、NSE、CA125和CA242标志物水平,灵敏度为94.2%,特异性为76.5%,准确率为69.4%;单一检测血清CEA、CYFRA21-1、NSE、CA125和CA242灵敏度分别为64.2%、68.3%、51.9%、54.7%和55.6%,特异性分别为87.5%、61.2%、81.2%、81.6%和79.6%,准确率分别为59.7%、41.6%、42.4%、42.1%和61.2%;联合检测灵敏度与准确率均高于单一检测,差异均有统计学意义(均P<0.05)。结论应用血清CEA、CYFRA21-1、NSE、CA125和CA242联合检测,可提升肺癌诊断准确率,有助于早诊断、早治疗。
Objective To analyze of serum carcinoembryonic antigen（CEA）,cytokeratin 19 fragment（CYFRA21-1）,neuron specific enolase（NSE）,carbohydrate antigen 125（CA125） and carbohydrate antigen 242（CA242） combined detection on diagnostic accuracy in lung cancer. Methods One hundred and two patients with lung cancer treated at Nantong Tumour Hospital from June 2015 to December2016 were selected as the study group and 102 patients with benign pulmonary disease diagnosed by chest Xray or chest CT in the same period were selected as the control group. Serum CEA,CYFRA21-1,NSE,CA125 and CA242 combined detection was performed in both groups. Changes in the 5 serum markers were compared between the two groups. Results Compared with the control group,the 5 serum markers significantly increased in the study group（all P〈0. 05）. For patients in the study group,the serum CEA,CYFRA21-1,NSE,CA125 and CA242 levels varied significantly at different stages of disease（P〈0. 05）.For the combined detection of serum CEA,CYFRA21-1,NSE,CA125 and CA242 markers,the sensitivity was 94. 2%,specificity was 76. 5% and the accuracy rate was 69. 4%. For the dection of a single serum tumor marker,the sensitivity was 64. 2%,68. 3%,51. 9%,54. 7% and 55. 6%,respectively,and the specificity was 87. 5%,61. 2%,81. 2%,81. 6% and 79. 6%,respectively,and the accurate rate was59. 7%,41. 6%,42. 4%,42. 1% and 61. 2%,respectively. The sensitivity and accuracy were higher for the combined detection than for the single detection（all P〈0. 05）. Conclusion Combined detection of serum CEA,CYFRA21-1,NSE,CA125 and CA242 can improve the diagnostic accuracy of lung cancer,which is helpful to early diagnosis and treatment of lung disease.
出处
《中国肿瘤临床与康复》
2017年第6期660-662,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
河南省医学科技攻关计划项目(201602303)
