摘要
背景:间充质干细胞具有自我更新、多向分化以及免疫调节能力,已经成为当前研究的热点。目的:总结间充质干细胞对多种免疫细胞的调控作用以及在临床免疫相关疾病治疗中的应用。方法:以"mesenchymal stem cells,immunomodulation,MSC1 and MSC2,autoimmune diseases,间充质干细胞,免疫调节,自身免疫病"为检索词,由第一作者检索Pub Med数据库和CKNI数据库1974年1月至2016年12月相关文献。最终选取52篇代表文献。结果与结论:间充质干细胞能够抑制T淋巴细胞功能、降低B细胞的活化增殖及抗体分泌、影响巨噬细胞极化、抑制树突状细胞的成熟、抑制NK细胞的增殖和毒性,故其具有治疗免疫相关疾病的巨大潜力。但是间充质干细胞在不同炎症微环境作用下能够表现出截然相反的免疫调节能力,并且关于这一现象明确又可控的机制仍不完全清楚,所以间充质干细胞在临床免疫相关疾病中发挥作用的具体机制是未来的研究方向。
BACKGROUND： Mesenchymal stem cells （MSCs） have the abilities of self-renewal, multidirectional differentiation and immunomodulation, and have become the focus of current research. OBJECTIVE： To summarize the immunomodulation of MSCs to different immune cells and the clinical applications of MSCs in the treatment of immune-related diseases. METHODS： The first author searched the PubMed and the CKNI databases for relative articles from January 1974 to December 2016. The key words were ＂mesenchymal stem cells, immunomodulation, MSC1 and MSC2, autoimmune diseases＂ in English and Chinese, respectively. Finally, 52 representative articles were included. RESULTS AND CONCLUSION： MSCs can inhibit the function of T lymphocytes, reduce the activation, proliferation and antibody secretion of B lymphocytes, affect the polarization of macrophages, inhibit the maturation of dendritic cells, inhibit the proliferation and toxicity of NK cells, so MSCs have the great potential in the treatment of immune-related diseases. However, MSCs exhibit the opposite immunomodulatory abilities under different inflammatory microenvironments, and moreover the definite and controllable mechanism of this phenomenon is still unclear, Therefore, future investigations may focus on the specific mechanism of MSCs in the clinical treatment of immune-related diseases.
作者
杨燕美
江小霞
温宁
Yang Yan-mei Jiang Xiao-xia Wen Ning(Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China)
出处
《中国组织工程研究》
CAS
北大核心
2017年第17期2776-2782,共7页
Chinese Journal of Tissue Engineering Research
基金
国家863计划(2013AA032201)
北京市自然科学基金资助项目(7162142)
国家自然科学基金(81271936)~~
