摘要
目的探讨原发性高血压患者并发左心室舒张功能不全(LVDD)的危险因素及预防对策。方法以原发性高血压患者168例为研究对象,行超声心动图检查并检测计算二尖瓣瓣尖舒张早期最大血流速度(E)与晚期最大血流速度(A)的比值E/A,根据E/A将患者分为LVDD组(E/A≥1,n=92)和高血压组(E/A<1,n=76)。结果与高血压组比较,LVDD组年龄和身体质量指数升高,高血压病程延长,血压变异性和脉压指数增加,合并高脂血症率、合并糖尿病率、合并房颤率亦升高(P<0.05),年龄、身体质量指数、高血压病程、血压变异性、脉压指数、合并高脂血症、合并糖尿病、合并房颤为原发性高血压患者并发LVDD的相关因素。采用Logistic多因素分析法对上述相关因素进一步进行分析,结果显示,年龄、高血压病程、血压变异性、脉压指数、合并高脂血症、合并糖尿病、合并房颤均为原发性高血压患者并发LVDD的独立危险因素。结论原发性高血压患者并发LVDD的危险因素有年龄、高血压病程、血压变异性、脉压指数、合并高脂血症、合并糖尿病、合并房颤等,积极采取措施对合并上述相关危险因素的原发性高血压患者进行干预有利于其LVDD的预防。
Objective To explore risk factors and preventive measures of patients with primary hypertension complicated with left ventricular diastolic dysfunction （LVDD）. Methods 168 patients with primary hypertension were selected as research objects and they underwent echocardiography examination.Ratio of early maximum blood flow velocity （E） and late maximum blood flow velocity （A） E/A was detected and calculated.According to E/S,patients were divided into LVDD group （E/A 〉 1,n=92） and the hypertension group （E/A 〈 1,n=76）. Results Compared with the hypertension group,age and body mass index of LVDD group were increased.In addition,hypertension duration was prolonged,blood pressure variability and pulse pressure index were increased,complicated hyperlipidemia rate,complicated diabetes rate and complicated atrial fibrillation rate were also improved （P 〈 0.05）.Age,body mass index, hypertension duration,blood pressure variability,pulse pressure index,complicated hyperlipidemia,complieated diabetes and complicated atrial fibrillation were correlated factors for patients with primary hypertension complicated with LVDD.Above correlated factors were further analyzed by Logistic multi-factor analysis method.The result showed that age,body mass index,hypertension duration,blood pressure variability,pulse pressure index,complicated hyperlipidemia,complicated diabetes and complicated atrial fibrillation were all independent risk factors for patients with primary hypertension complicated with LVDD. Conclusion Risk factors for patients with primary hypertension complicated with LVDD were age,body mass index,hypertension duration,blood pressure variability,pulse pressure index,complicated hyperlipidemia,complieated diabetes rate and complicated atrial fibrillation and so on.Intervention by timely measures for patients with primary hypertension complicated with above risk factors is helpful for prevention of LVDD.
作者
杨海涛
梁艳
YANG Haitao LIANG Yar(Department of General Medieine,Longgang District People＇ s Hospital of Shenzhen,Shenzhen 518116,China Department of General Medieine,Guanlan People＇ s Hospital of Shenzhen, Shenzhen 518116,China)
出处
《中国医药科学》
2017年第10期139-142,共4页
China Medicine And Pharmacy
关键词
原发性高血压
左心室舒张功能不全
危险因素
预防
对策
Primary hypertension
Left ventricular diastolic dysfunction
Risk factors
Prevention
Measures
