摘要
糖尿病肾脏疾病（DKD）是糖尿病最严重的慢性并发症之一。目前认为DKD的发生、发展是多因素共同作用的结果，包括氧化应激、炎性反应、纤维化以及自噬等，而其中高血糖是最关键的，它是发生肾脏损害的先决条件。柚皮苷（4’，5，7．三羟二氢黄酮-7-鼠李葡萄糖苷）是一种从芸香科柑橘属植物柚中提取的双氢黄酮类化合物，具有多种药理活性，如抗炎、抗氧化应激、改善胰岛素抵抗、调节糖、脂代谢、抗纤维化等，可能从根本上延缓DKD的进展。
Diabetic kidney diseases （DKD） are one of the most severe chronic complications of diabetes mellitus. At present, it is thought that the development of DKD are the results of many factors, including oxidative stress, inflammation, fibrosis and autophagy, etc. Among which high blood glucose is the most critical. It is the precondition of kidney damage. Narlngin （4＇ ,5,7-trlhydroxy flavonone-7-rhamnoglucoside）, the major flavonoid in grapefruit juices has been shown to possess pharmacological properties such as antiinflammatory, antioxidant effects, improving insulin resistance, regulating the metabolism of glucose and fat and antifibrosis, which may cundamentally improve the process of DKD.
出处
《国际内分泌代谢杂志》
2017年第4期239-241,253,共4页
International Journal of Endocrinology and Metabolism
基金
辽宁省教育厅科学研究一般项目（L2015564）
辽宁省高等学校“高端人才队伍建设工程”（2014187）
关键词
糖尿病
糖尿病肾脏疾病
柚皮苷
Diabetes mellitus
Diabetic kidney diseases
Naringin
