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腹腔注射白细胞介素-2治疗肝硬化腹腔积液并自发性腹膜炎的效果观察 被引量:7

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摘要 目的观察腹腔注射白细胞介素-2(IL-2)治疗肝硬化腹腔积液合并自发性腹膜炎的疗效。方法将83例患者分为观察组45例,对照组38例,两组均常规处理,观察组加用160万U的IL-2腹腔注射,隔天1次,疗程2周。结果观察组治疗后腹胀、腹痛现象明显减少,与对照组治疗后比较差异有统计学意义(P<0.05)。两组治疗后肝功能、血常规均明显改善(P<0.05),其中观察组治疗后总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)低于对照组(P>0.05)。两组治疗后,白细胞计数(WBC)、中性粒细胞(PMN)和降钙素原(PCT)均明显改善(P<0.05),且治疗后上述指标改善情况观察组优于对照组(P<0.05)。观察组治疗后细菌培养阳性比例明显降低(P<0.05),且同时低于对照组(P<0.05)。治疗及随访1个月内两组均未出现明显不良反应。结论腹腔注射IL-2可提高治疗肝硬化腹腔积液合并自发性腹膜炎患者治疗效果,对控制腹水感染效果尤佳。
出处 《广东医学》 CAS 北大核心 2017年第13期2052-2053,共2页 Guangdong Medical Journal
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