摘要
目的探讨槐杞黄颗粒对儿童原发性肾病综合征(PNS)的治疗作用及对细胞、体液免疫的影响。方法采用前瞻性研究方法将68例住院并初诊为PNS的患儿随机分为泼尼松联合槐杞黄颗粒治疗组(观察组,33例)和单用泼尼松治疗组(对照组,35例)。比较两组患儿随访至9个月时PNS复发率、维持缓解率、感染发生率,6个月时隔日泼尼松用量及3、6、9个月时血清白蛋白、胆固醇水平及细胞、体液免疫功能。结果观察组的感染发生率低于对照组,差异有统计学意义(P<0.05),无复发维持缓解率高于对照组,差异有统计学意义(P<0.05),6个月时隔日泼尼松用量小于对照组,差异有统计学意义(P<0.05);随访至3、6个月时,两组血清白蛋白、胆固醇水平及细胞、体液免疫学指标检测差异均无统计学意义(P均>0.05),至9个月时观察组血清白蛋白明显高于对照组,差异有统计学意义(P<0.001),胆固醇两组比较差异无统计学意义(P>0.05),观察组CD3、CD4、CD19、NK百分比和血清IgA、IgG、IgM水平明显提高,CD8百分比明显降低,CD4/CD8比率明显增高,与对照组比较差异均有统计学意义(P<0.05、P<0.01或P<0.001);未发现槐杞黄相关的不良反应。结论槐杞黄可减少PNS患儿复发率、维持较长时间的缓解,减少感染发生率及泼尼松用量,长期应用可提高PNS患儿的细胞和体液免疫功能,且显示了其治疗的安全性,对血浆胆固醇水平无影响。
Objective To discuss the effects of Huaiqihuang particles on child primary nephrotic syndrome （PNS） and its effects on cellular and humoral immune function. Methods A randomly prospective study was used to divide 68 children with PNS into an observation group and a control group. In the observation group, 33 children were treated with Huaiqihuang particles combined with glucocorticoid. Thirty-five children in the control group were treated with glucocorticoid alone. A series of indicators were observed and compared, including the rates of PNS infection, recurrence and remission in the 9-month follow-up, the dosage of qod glucocor-ticoid in the 6-month follow-up, and the levels of serum albumin and cholesterol, as well as the immune func tion of cells and humors in the third, the sixth and the ninth months. Results Compared with the control group, the infection rate of the observation group was lower, there was statistical difference （ P〈0.05）, the nonrecurrence remission rate was higher, there was statistical difference （ P〈0.05） and the dosage o{ qod glu- cocorticoid in the sixth month was less than the control group, there was statistical difference （ P〈0.05）. In the 3- and 6- month follow-up, comparison of the levels of serum albumin and cholesterol and the immunologi- cal indexes of cells and humors yielded no statistical differences between the two groups （all P -0.05）. In the ninth month, the level of serum albumin in the observation group was significantly higher than that in the control group, there was statistically significant difference （ P〈0.001）, while comparing the level of cholesterol showed no significant difference between the two groups （ P〉0.05）. Compared with the control group, the observation group had higher percents of CD3, CD4, CD19, NK, and higher ratio of CD4 to CDS, and higher levels of IgA, IgG, IgM, and lower percent of CD8, there were all statistical differences between the two groups （ P〈0.05, P〈0.01 or P 〈0. 001）. There were no adverse effects related to Huaiqihuang particles.Conclusion Huaiqihuang particles are effective in treating children with PNS by reducing the rates of infection and recurrence and the dosage of glucocorticoid, and maintaining a longer remission as well. Besides, a long- term medication of Huaiqihuang particles can improve the immune function of cells and humors in children with PNS, which shows that treatment with Huaiqihuang particle is safe, with no influence on the level of plasma cholesterol.
出处
《右江民族医学院学报》
2017年第3期163-167,共5页
Journal of Youjiang Medical University for Nationalities
基金
国家自然科学基金(30460137
81460143)
广西教育厅科研基金重点资助项目(ZD2014102)
