摘要
目的评估双歧杆菌BB-12对婴幼儿腹泻治疗的有效性和安全性。方法对2015年12月至2016年8月吉林大学白求恩第一医院小儿消化内科诊治的120例腹泻患儿,采用随机、单盲方法,分为双歧杆菌BB-12治疗组、枯草杆菌二联活菌阳性对照组、未添加益生菌的安慰剂组,各40例。均配合蒙脱石散及补液等对症治疗,比较各组病例临床资料并进行分析。结果治疗组的显效率及有效率分别为37.50%、52.50%,阳性对照组为42.50%、42.50%,安慰剂组为17.50%、52.50%,差异有统计学意义(P<0.05),治疗组与阳性对照组相比,差异无统计学意义(P>0.05)。3组大便次数:第4天治疗组(3.10±1.41)次/d、阳性对照组(3.05±1.63)次/d、安慰剂组(3.93±1.91)次/d;第7天治疗组(1.45±0.64)次/d、阳性对照组(1.43±0.90)次/d、安慰剂组(1.95±1.30)次/d,3组较治疗前均明显减少,差异有统计学意义(P<0.05)。但治疗组与阳性对照组相比,差异无统计学意义(P>0.05),与安慰剂组比较差异有统计学意义(P<0.05)。3组患儿治疗后腹泻好转所需天数方面,治疗组、阳性对照组及安慰剂组分别为(4.20±1.32)d、(4.40±1.37)d、(5.18±1.57)d,3组差异有统计学意义(P<0.05),但治疗组与阳性对照组相比,差异无统计学意义(P>0.05)。结论双歧杆菌BB-12治疗婴幼儿腹泻安全有效。
Objective To evaluate the efficacy and safety of bifidobacterium BB- 12 in treatment of children with acute diarrhea. Methods In this single-blind study, 120 infant patients with diarrhea treated in the First Hospital of Jilin University from Dee 2015 to Aug 2016 were randomized into three groups: (1)treatment group:treated with Bifidobacterium BB-12; (2)positive control group:treated with live combined Bacillus subtilis and Enteroeoecus faeeium ; (3)placebo group : treated with maltodextrin. There were 40 patients in each group, and all received montmorillonite and fluid re- placement. Clinical data of each group were analyzed and compared. Results The significant efficiency and efficiency of the treatment group was 37.50% and 52.50%, the positive control group was 42.50% and 42.50%, the placebo group was 17.50% and 52.50%. The treatment group had no significant difference with the positive control group, but significantly higher than that of the placebo group ; At the 4th day, the frequency of patients' defecation of the treatment group was (3.10 ± 1.41 )/d, the positive control group was (3.05±1.63 )/d, the placebo group was (3.93 ±1.91 )/d, at the 7th day, the frequency of patients' defecation of the treatment group was (1.45 ±0.64)/d, the positive control group was (1.43±0.90)/d, the placebo group was (1.95±1.30)/d, the treatment group was similar to the positive control group, and was significantly less than the placebo group. The average duration of diarrhea of each group was (4.20±1.32) d, (4.40±1.37) d, (5.18± 1.57) d. Conclusion Bifidobacterium BB- 12 is safe and effective in the treatment of infantile diarrhea.
出处
《中国实用儿科杂志》
CSCD
北大核心
2017年第7期539-542,共4页
Chinese Journal of Practical Pediatrics
关键词
双歧杆菌BB-12
枯草杆菌二联活菌
腹泻
婴幼儿
Bifidobacterium BB-12
live combined bacillus subtilis and enteroeoecus faeeium
diarrhea
infant