摘要
通过对20世纪80年代以来的30多年的文献进行分析总结,简述了酸枣仁汤的物质基础及成分分析方法、工艺及剂型研究、临床应用、药理作用。分析表明,酸枣仁汤在治疗失眠、焦虑、抑郁、神经官能症等方面较为明显;药理学方面,酸枣仁汤通过提升受试动物脑内单胺类神经递质,抑制一氧化氮合酶降低一氧化氮含量,改善脑中神经组织细胞的损伤程度来抗抑郁、抗失眠、提升学习记忆能力;工艺学研究主要体现在提取工艺的研究,而新剂型的研究则主要体现在配方颗粒的研究。但酸枣仁汤的药学研究目前还停留在较为初级的研究阶段。从中药新药研发的角度来看,需要进行更为深入的研究。
By analyzing and summarizing the literature for more than 30 years since 1980＇ , the article describes chemical composition and material basis of Ziziphi Spinosae decoction, dosage form preparation technology, pharmacological effects and clinical application respectively. The results showed that, the famous decoction had a wide application and definite curative effect, and it was very effective in the treatment of insomnia, anxiety, de- pression and neurosis. Pharmacological research references showed that this classic decoction had the ability of improvement of the monoamine neurotransmitter, depression of the nitric oxide synthase and deduction of the content of carbon monoxide, then the damage degree of the nerve tissue cells in the brain would be decreased significantly. Processing research main reflected in extraction process of research, and new formulations of re- search was main reflected in formula particles of research. Pharmaceutical study of Ziziphi Spinosae decoction was currently still in the relatively early stages of research. From the research and development of new drugs of tradi- tional Chinese medicine point of view, it needs to have a further study.
作者
房蕴歌
商利娜
田雷
郝丽静
赵清
FANG Yunge SHANG Lina TIAN Lei HAO Lijing ZHAO Qing(Department of Traditional Chinese Medicine, Hebei University, Baoding 071000, China Hebei Hemu Liyuan Agricultural Science and Technology Co., Ltd., Baoding 071000, China)
出处
《医学研究与教育》
CAS
2017年第3期61-67,共7页
Medical Research and Education
基金
河北大学校企合作项目(706800017018)
关键词
酸枣仁汤
化学成分
临床应用
药理作用
工艺学研究
Ziziphi Spinosae decoction
chemical composition
clinical application
pharmacological effects
technology research
