期刊文献+

干细胞转录因子OCT4、SOX2在食管鳞癌中的表达及与预后的关系 被引量:5

Expressions of OCT4 and SOX2 in esophageal squamous cell carcinoma and their relationships with clinical prognosis
下载PDF
导出
摘要 目的探讨干细胞转录因子Sry相关HMG盒2(SOX2)、八聚体结合转录因子4(OCT4)在食管鳞癌中的表达变化及与患者临床特征、预后的关系。方法采用免疫组织化学SP法检测77例手术后经病理学证实为食管鳞癌的手术标本(食管癌组)和40例癌旁组织标本(癌旁组织)中SOX2、OCT4蛋白的表达水平,并分析其与患者临床特征、预后的关系。结果食管癌组织中的SOX2蛋白、OCT4蛋白阳性表达率分别为63.64%和77.92%均高于癌旁组织的17.50%和15.00%,且差异具有统计学意义(P<0.05);食管癌组织中的SOX2蛋白、Oct4蛋白在低分化、淋巴结转移患者中呈高表达(P<0.05);食管癌组织中的SOX2蛋白阳性表达患者的3年随访中位生存期24个月低于阴性患者的30个月(χ~2=4.072,P=0.044);OCT4蛋白阳性表达患者的中位生存时间21个月低于阴性患者33个月(χ~2=4.880,P=0.037)。结论 SOX2、OCT4蛋白在食管癌组织中高表达,并且与患者的分化程度、转移及预后有关。 To investigate the expressions of stem cell transcription factor Sry related HMG box 2(SOX2) and eight dimer binding transcription factor 4 (OCT4) in esophageal squamous cell carcinoma and their re- lationships with clinical characteristics and prognosis. Methods The expression levels of SOX2 and OCT4 proteins were detected by immunohistochemical SP method in 77 cases of esophageal squamous cell carcinoma (esophageal cancer) tissues and 40 cases of paracancerous tissues (adjacent tissues), and their correlations with the clinical fea-tures and prognosis of the patients were analyzed. Results The positive expression rates of SOX2 protein and OCT4 protein in the esophageal cancer tissues (63.64% and 77.92% respectively) were significantly higher than those in the adjacent tissues (17.50% and 15.00% respectively, p〈 0.05). SOX2 protein and OCT4 protein were highly ex-pressed in the esophageal cancer tissues of the patients with poorly-differentiated cancer and lymph node metastasis( p〈 0.05). In the patients with positive expression of SOX2 protein in the esophageal carcinoma tissues, the median survival time during the three-year follow-up was 24 months, which was significantly shorter than that (30 months) of the SOX2 negative patients (x2 = 4.072, p= 0.044). The median survival time of the patients with positive OCT4 protein expression (21 months) was significantly shorter than that (33 months) of the OCT4 negative patients (x2 =4.880,p = 0.037). Conclusions SOX2 and OCT4 proteins are highly expressed in esophageal cancer, and correlated with the degree of differentiation, metastasis and prognosis.
出处 《中国现代医学杂志》 CAS 北大核心 2017年第13期58-62,共5页 China Journal of Modern Medicine
关键词 Sry相关HMG盒2 八聚体结合转录因子4 食管鳞癌 表达 预后 Sry related HMG box 2 eight dimer binding transcription factor 4 esophageal squamous cell carcinoma expression prognosis
  • 相关文献

参考文献10

二级参考文献92

  • 1李会庆,刁玉涛,李颢,周英智,杨艳芳,房学强,王燕,吴侃,赵德利,周瑞雪,雷复华.肥城市食管鳞癌的危险因素研究[J].中华预防医学杂志,2007(S01):56-61. 被引量:10
  • 2温登瑰,刘志才,张立玮,王俊和,李永伟,马彩芬,李海平,王丹妮,连士勇,王士杰.河北涉县、磁县及河南林州市、山西阳城县上消化道癌集中高发对病因及预防的启示[J].中华预防医学杂志,2007(S01):6-8. 被引量:10
  • 3张理义,徐志熊.脑电超慢涨落图技术在心理疾病中的应用[J].中国行为医学科学,2006,15(6):569-570. 被引量:19
  • 4孙喜斌,刘志才,刘曙正,李变云,戴涤新,全培良,程兰平,陆建邦.林州市食管癌和胃癌的发病水平及变化趋势[J].中华肿瘤杂志,2007,29(10):764-767. 被引量:22
  • 5Pan H, Cai S, Ji J, et al. The impact of nutritional status, nutritional risk, and nutritional treatment on clinical outcome of 2248 hospitalized cancer patients: a multi-center, prospective cohort study in Chinese teaching hospitals [ J]. Nutr Cancer, 2013,65( 1 ) :62-70.
  • 6Argiles JM, Moore-Carrasco R, Fuster G, et al. Cancer cachexia : the molecular mechanisms[ J]. Int J Biochem Cell Biol, 2003,35 (4) :405-409.
  • 7Skipworth R J, Stewart GD, Dejong CH, et al. Pathophysiology of cancer eachexia: much more than host-tumour interaction? [ J]. Clin Nutr, 2007,26(6) :667-676.
  • 8Deans C, Wigmore SJ. Systemic inflammation, cachexia and prognosis in patients with cancer[ J]. Curr Opin Clin Nutr Metab Care, 2005,8 (3) :265-269.
  • 9Evans WJ, Morley JE, Argiles J, et al. Cachexia: a new definition [ J]. Clin Nutr, 2008,27 (7) :793-799.
  • 10Muscaritoli M, Anker SD, Argiles J, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics" [ J ]. Clin Nutr, 2010,29 (2) : 154-159.

共引文献89

同被引文献25

引证文献5

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部