摘要
目前尚无适用于中药辐照合理剂量设定的标准,为了规范中药辐照剂量的设定,本试验参考ISO 11137的标准抗性分布(SDR),计算中药辐照的理论剂量,并与9种中药粉和1种丸剂的实际系列辐照剂量进行比对。结果表明,丸剂和个别中药粉理论剂量比实际剂量偏小,达到-88%^-50%;有7种中药粉的理论剂量与实际剂量基本一致,偏差约为1k Gy。推断大部分中药粉可以通过SDR计算出合理的理论剂量,但对丸剂不建议按照SDR直接进行辐照剂量设定。本研究结果有效地提高了中药合理剂量筛选的效率,降低辐照风险,为中药辐照灭菌剂量的合理设定提供了方法参考。
So far,there is none of standard for Chinese medicine radiation dose setting. To regulate and demonstrate radiation dose setting of Chinese medicine,it could be calculated theoretical dose by standard distribution of resistances（ SDR）. Nine kinds of Chinese medicine powder and one kind of pills were chosen to be radiated in this paper. It could be calculated deviation by comparring theoretical dose with practice dose and calculate deviation. The results show that theoretical dose of seven kinds of Chinese medicine powder can reach practice dose. Deviation is about 1k Gy. Deviation of pills and some Chinese medicine powder is very big. It is about from-88% to-50%. It is possible to make a decision that most Chinese medicine powder could get reasonable dose by SDR. Do not set radiation dose of pills by SDR. In this paper,we give a demonstration of reasonable radiation sterilization dose setting. Increase efficiency and decrease the risk for radiation sterilization dose setting.
作者
陈伟盛
简敏骞
关倩明
江英桥
CHEN Weisheng JIAN Minqian GUAN Qianming JIANG Yingqiao(Guangzhou Institute for Drug and Control, Guangzhou, Guangdong 510160)
出处
《核农学报》
CAS
CSCD
北大核心
2017年第8期1515-1520,共6页
Journal of Nuclear Agricultural Sciences
基金
国家技术重大专项-中药质量安全检测和风险控制技术平台(2014ZX09304307-002-005)
关键词
中药
辐照
剂量设定
标准抗性分布
Chinese medicine
radiation
dose setting
standard distribution of resistances
