摘要
目的:探讨个体化肠内营养支持对重症脑卒中患者的临床效果。方法:120例重症脑卒中需营养支持的患者按住院号单双数分为两组,试验组60例给予个体化肠内营养支持,根据病情给予不同配方、浓度的营养液,必要时添加微量元素;对照组60例给予标准配方的整蛋白肠内营养液。两组热量供给均为83~125 kJ·kg^(-1)·d^(-1)。比较营养支持前和营养支持21d后两组患者血清白蛋白(Alb)、前白蛋白(PA)、血红蛋白(Hb)、维生素C(VC)的变化,观察肺部感染、胃肠道不良反应等并发症发生情况,记录住院天数和住院费用。结果:营养支持21 d后,试验组患者血清Alb、PA、Hb、VC水平较治疗前无明显变化(P>0.05),且血清Alb、PA、VC水平显著高于对照组(P<0.05)。试验组患者并发症发生率明显低于对照组(P<0.05),住院天数和住院费用均低于对照组(P<0.05)。结论:个体化营养支持可改善重症脑卒中患者的营养状况,降低并发症发生率,减少住院时间,值得临床推广使用。
Objective： To evaluate the clinical effect of individualized enteral nutritional （EN） support in severe stroke patients. Methods： Totally 120 severe stroke patients with nutritional risk were divided into two groups according to single or double admission number. The 60 patients in the intervention group received an individualized EN with different formula and concentrations according to the clinical status, and supplemented trace elements as occasion required. In the routine group, the patients received EN with standard formula. The energy supply was 83-125 kJ·kg^-1·d^-1 in both groups. Blood albumin（Alb）, pre-albumin（PA）, hemoglobin（Hb） and vitamin C（VC） were examined before and after the 21-day nutritional support. The lung infection and gastrointestinal （GI） complications were observed, and the hospital stay and cost were recorded as well. Results： After 21 day＇s nutrition support, the serum levels of Alb, PA and VC in the intervention group were not statisticly significant than before （ P 〉 0.05 ）, and the serum levels of Alb, PA and VC were significantly higher than those in the routine group（ P 〈 0.05）. The incidence of complications in the in the in-tervention group was lower than that in the routine group （ P 〈 0.05 ）, and the length of hospital stay and hospitalization was shorter than that in the routine group （P 〈 0.05 ）. Conclusion： Individualized enteral nutritional support can significantly improve nutritional status, reduce inflammation reactions and GI complications in severe stroke patients, which is worthy of clinical use.
出处
《中国药师》
CAS
2017年第7期1265-1267,共3页
China Pharmacist
基金
2013年川北医学院科研发展计划项目(编号:CBY13-B-QN15)
关键词
重症脑卒中
个体化营养支持
肠内营养
Severe stroke patients
Individualized nutritional support
Enteral nutrition
