摘要
目的:探讨晚期前列腺癌间歇性雄激素剥夺治疗(IADT)和持续性雄激素剥夺治疗(CADT)两种不同方式与继发糖尿病(DM)和糖耐量异常(IGT)风险的相关性。方法:对2013年1月至2015年12月于我院进行雄激素剥夺治疗(ADT)的PCa患者进行回顾性病例对照研究。通过监测患者空腹血糖、餐后2 h血糖及口服糖耐量试验,结合患者相关临床症状,对IADT和CADT引起DM和IGT的风险进行统计学分析,并分析组内体质量指数(BMI)、高血压、吸烟、饮酒等因素与继发性DM和IGT的关系。结果:IADT组53例(46.5%),平均(69.1±4.3)岁;CADT组61例(53.5%),平均(70.2±5.7)岁,两组在临床特点方面均无明显差异(P均>0.05);IADT组BMI、高血压、吸烟、饮酒等因素对DM、IGT的发生均无明显影响(P均>0.05),CADT组BMI、高血压、吸烟、饮酒因素对DM、IGT的发生均无明显影响(P均>0.05);IADT组与CADT组比较,DM的发生无统计学意义(P=0.64);但IGT的发生有统计学意义(P=0.03)。结论:IADT与CADT比较,PCa患者的IGT发生风险更低,安全性更高。
Objective： To investigate the correlation of intermittent androgen-deprivation therapy （IADT） and continuous an- drogen-deprivation therapy （CADT） for advanced prostate cancer （PCa） with the risks of secondary diabetes mellitus （DM） and im- paired glucose tolerance （IGT）. Methods ： We conducted a retrospective case-control study of the advanced PCa patients treated by IADT or CADT in our hospital from January 2013 to December 2015. Based on the levels fasting blood glucose and 2-hour postprandial blood glucose, results of oral glucose tolerance test, and clinical symptoms of the patients, we statistically analyzed the IADT- or CADT-related risk factors for DM and IGT and the relationship of the body mass index （BMI） , hypertension, smoking, and alcohol consumption with secondary DM and 1GT. Results： IADT was given to 53 （46.5%） of the patients, aged （69. 1 ± 4.3） years, and CADT to 61 （53.5%）, aged （70.2± 5.7） years. No statistically significant differences were observed in clinical characteristics between the two groups of patients （P 〉 0.05）. BMI, blood pressure, smoking and drinking exhibited no significant influence on the development of DM or IGT either in the IADT （ P 〉 0.05 ） or the CADT group. The incidence of IGT was significantly lower in the IADT than in the CADT group （ P = 0.03 ）, but that of DM showed no statistically significant difference between the two groups （ P =0.64）. Conclusion ： Compared with CADT, IADT has a lower risk of IGT and a higher safety in the treatment of advanced prostate cancer.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2017年第7期598-602,共5页
National Journal of Andrology
关键词
前列腺癌
间歇性雄激素剥夺治疗
持续性雄激素剥夺治疗
糖尿病
糖耐量异常
prostate cancer
intermittent androgen-deprivation therapy
continuous androgen-deprivation therapy
diabetes mel-litus
impaired glucose tolerance
