摘要
目的探究三代头孢抗菌药物在糖尿病并发泌尿系统感染患者中的疗效。方法选取2012年1月-2015年6月医院收治的泌尿系统感染的糖尿病患者86例作为研究对象,将研究对象按照随机数表法分成三组,A组患者29例,B组患者29例,C组患者28例,三组患者分别给予三种三代头孢抗菌药物进行治疗,A组患者静脉滴注头孢他啶治疗;B组患者静脉滴注头孢曲松治疗;C组患者静脉滴注头孢噻肟治疗,分析三组患者的病原菌的类型以及分布情况,比较三组患者的治疗效果、病原菌的清除率及不良反应发生率。结果 86例患者共检出病原菌133株,革兰阴性菌98株占73.68%,革兰阳性菌30株占22.56%,真菌5株占2.76%;治疗一个疗程后,C组患者治疗的有效率最高为75.00%,其次为B组和A组,分别是58.62%和65.52%,三组比较差异有统计学意义(P<0.05),三组患者细菌清除率最高的是C组为73.33%,A组和B组的细菌清除率分别为62.79%和64.44%,三组比较差异有统计学意义(P<0.05)。三组患者在治疗结束之后均有部分患者出现不良反应,A、B、C组患者的不良反应率分别为20.86%、17.24%、7.14%。三组患者比较差异有统计学意义(P<0.05)。结论三代头孢抗菌药物中,头孢噻肟治疗糖尿病并发泌尿系统感染的效果最好,其次是头孢曲松和头孢他啶,但三种抗菌药物均会引起不良反应。
OBJECTIVE To explore the efficacy of third generation cephalosporins in treatment of diabetes patients complicated with urinary tract infections.METHODS A total of 86 diabetes patients complicated with urinary tract infections who were treated in the hospital from Jan 2012 to Jun 2015 were recruited as the study objects and randomly divided into three groups：the group A with 29 cases,the group B with 29 cases,and the group C with 28 cases.The three groups of patients were treated with three types of third generation cephalosporins,the group A was given intravenous drip of ceftazidime,the group B was given intravenous drip of ceftriaxone,and the group C was given intravenous drip of cefotaxime.The distribution of species of pathogens was observed;the therapeutic effect,clearance rate of pathogens,and incidence of adverse reactions were compared among the three groups of patients.RESULTS Totally 133 strains of pathogens were isolated from the 86 patients,including 98（73.68%）strains of gram-negative bacteria,30（22.56%）strains of gram-positive bacteria,and 5（2.76%）strains of fungi.The effective rate of treatment of the group C was highest（75.00%）,followed by the group B（58.62%）and the group A（65.52%）,and there was significant difference among the three groups（P〈0.05）.The clearance rate of bacteria was 73.33%in the group C,62.79%in the group A,64.44%in the group B,and there was significant difference among the three groups（P〈0.05）.There were some patients who had adverse reactions in the three groups after the treatment;the incidence of adverse reactions was 20.86%in the group A,17.24%in the group B,7.14%in the group C,and there was significant difference among the three groups of patients（P〈0.05）.CONCLUSION Among the third generation cephalosporins,cefotaxime has the most remarkable effect on treatment of the diabetes patients complicated with urinary tract infection,followed by ceftriaxone and ceftazidime,however,the three types of antibiotics may induce the adverse reactions.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第13期2999-3001,3005,共4页
Chinese Journal of Nosocomiology
