摘要
目的观察参松养心胶囊联合小剂量琥珀酸美托洛尔缓释片对冠状动脉介入术后心律失常的疗效及炎性因子的影响。方法选取2013年5月~2016年5月广州市中西医结合医院及广东医科大学附属医院行冠脉介入术后心律失常患者134例,按随机数字表法分为三组,琥珀酸美托洛尔缓释片组(A组,46例,47.5 mg/d,1次/d),参松养心胶囊组(B组,45例,3粒/次,3次/d),参松养心胶囊联合小剂量琥珀酸美托洛尔缓释片组(C组,43例,3粒/次,3次/d;23.75 mg/次,1次/d)。随访3个月,比较三组治疗前后心律失常发生率及超敏C反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)等炎性因子水平。结果与治疗前比较,三组患者术后心律失常发生率、炎性因子水平均下降(P<0.05)。三组组间比较,与A组、B组比较,C组术后心律失常发生率最小(P<0.05),C组术后hs-CRP、TNF-α、IL-6明显降低(P<0.05)。结论参松养心胶囊联合小剂量琥珀酸美托洛尔缓释片可有效减少冠状动脉介入术后心律失常发生率,降低炎症反应。
Objective To observe the effect of Shensong Yangxin Capsule combined with low-dose Metoprolol Succinate Sustained-release Tablets on arrhythmia and inflammatory factors after percutaneous coronary intervention（PCI）.Meth- otis From May 2013 to May 2016,134 patients with arrhythmia after PCI in Guangzhou Traditional Chinese and West- ern Medicine Hospital and the Affiliated Hospital of Guangdong Medical University were divided into three groups by a random number table including Metoprolol Succinate Sustained Release Tablet group（group A;n=46;47.5 mg each time, and once per day）, Shensong Yangxin Capsule group（group B;n=45;3 capsules each time and thrice per day）, and Shen- song Yangxin Capsule combined with low-dose Metoprolol Succinate Sustained Release Tablets （group C;n=43;3 Shen-song Yangxin capsules each time and three times per day together with 23.75 mg Metoprolol Succinate Sustained release tablet, once per day）.The follow-up visits were lasted for 3 months.The incidence of arrhythmia and inflammatory factor levels including high-sensitivity C-reactive protein （hs-CRP）,tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） before and after therapy were compared.Results Compared with prior treatment,the incidence of arrhythmia and inflammatory factor levels after surgery among three groups were all lower （P〈0.05）.By inter-group comparisons, the incidence of arrhythmia was lowest in group C（P〈0.05） ,and the levels of hs-CRP,TNF-α and IL-6 in group C were sig- nificantly decreased（P〈0.05）.Conclusion Combination of Shensong Yangxin Capsule and low-dose of Metoprolol Succi- nate Sustained Release Tablets can effectively reduce the incidence of arrhythmia after PCI and decrease the inflammatory response.
出处
《中国当代医药》
2017年第19期36-38,43,共4页
China Modern Medicine
关键词
参松养心胶囊
琥珀酸美托洛尔缓释片
冠状动脉介入术
心律失常
炎性因子
Shensong Yangxin Capsule
Metoprolol suc-cinate Sustained-release Tablet
Percutaneous coronaryintervention
Arrhythmia
Inflammatory factors
