摘要
目的研究头孢曲松联合阿奇霉素治疗小儿急性下呼吸道感染的临床疗效。方法临床纳入该院2014年9月‐2016年9月收治的98例急性下呼吸道感染患儿作为研究对象,所有患儿均进行内科常规治疗。按随机数字表法分为两组各49例。其中49例患儿给予头孢曲松治疗作为对照组,另49例患儿在上述基础上联合阿奇霉素治疗作为观察组。观察两组患儿治疗效果、症状改善时间、生活质量以及不良反应情况等。结果观察组、对照组治疗总有效率分别为95.92%、81.63%,观察组明显高于对照组,差异有统计学意义(P<0.05)。观察组发热消退时间、喘息消失时间、咳嗽消失时间、肺部啰音消失时间以及平均住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗前两组患儿日常生活能力评分(ADL)、生存质量评分(QOL)差异无统计学意义(P>0.05);治疗后观察组ADL、QOL评分明显高于对照组,差异有统计学意义(P<0.05)。观察组、对照组不良反应发生率分别为12.24%、8.16%,两组对比差异无统计学意义(P>0.05)。结论头孢曲松联合阿奇霉素治疗急性下呼吸道感染患儿效果显著,有效缩短患儿治疗时间,药物治疗临床起效时间更快,生活质量明显提高,不良反应少,安全性高,值得临床应用及推广。
【Objective】To study the clinical efficacy of ceftriaxone combined with azithromycin in treatment of children with acute lower respiratory tract infection.【Methods】A total of 98 children with acute lower respiratory tract infection admitted to our hospital from September 2014 to September 2016 were enrolled in the study. All the patients were treated with routine medical treatment. According to the random number table method, they were divided into two groups, with 49 cases in each group. Fortynine cases treated with ceftriaxone were served as the control group, and the other 49 cases treated with azithromycin on the basis of the above treatment were served as the observation group. The therapeutic effect, symptom improvement time, quality of life and adverse reaction of the two groups were observed.【Results】The total effective rates of the observation group and the control group were 95.92% and 81.63% respectively, and the observation group was significantly higher than the control group（P 0.05）. The fever subsided time, wheezing disappearance time, cough disappearance time, pulmonary rales disappeared time and hospitalization time in the observation group were shorter than those in the control group（P 0.05）. Before treatment, there was no statistical difference between the two groups in Activities of Daily Living（ADL） score and Quality of Life（QOL） score（P 0.05）; after treatment, ADL and QOL scores of the observation group was significantly higher than those of the control group（P 0.05）. The incidence of adverse reactions in the observation group and the control group were 12.24% and 8.16% respectively, and there was no statistical difference between the two groups（P 0.05）.【Conclusion】Ceftriaxone combined with azithromycin in treatment of acute respiratory tract infection has significant effect, short treatment time and faster clinical onset time, can significantly improve the quality of life with less adverse reaction and high safety, which is worthy of clinical application and promotion.
作者
顾法欣
GU Faxin(Western Medicine Department, Heze City Hospital Heze, Shandong 2 74000, Chin)
出处
《中国医学工程》
2017年第6期43-47,共5页
China Medical Engineering
关键词
急性下呼吸道感染
头孢曲松
阿奇霉素
治疗效果
安全性
acute lower respiratory tract infection
ceftriaxone
azithromycin
treatment effect
safety
