摘要
目的:探讨影响原发性阴道癌预后的临床相关因素。方法:回顾性分析2003年1月至2015年1月广西医科大学附属肿瘤医院80例阴道恶性肿瘤患者临床资料。80例患者分为放疗组49例,其中二维放疗(two-dimensional radiotherapy 2DRT)组29例、三维放疗(three-dimensional radiotherapy 3DRT)组20例,比较两组的疗效和并发症;手术组31例,其中腹腔镜手术组16例、开腹手术组15例,评估腹腔镜手术在治疗原发性阴道癌中的可行性。结果:单因素生存分析结果显示FIGO分期、病理类型、肿瘤大小、阴道受侵长度与预后相关(均P<0.05),Cox多因素分析显示FIGO分期和病理类型为影响阴道癌预后的独立因素。2DRT组5年生存率20.90%与3DRT组的58.60%进行比较,差异具有统计学意义(P=0.022);2DRT组泌尿系统和消化道并发症的发生率为48.27%(14/29)和51.72%(15/29),分别与3DRT组的15.00%(3/20)和20.00%(4/20)进行比较,差异具有统计学意义(均P<0.05)。开腹手术组平均住院(57.00±41.75)天,多于腹腔镜手术组的(29.56±7.3)天,两组比较差异具有统计学意义(P=0.024)。结论:三维放疗及腹腔镜手术的应用,在未降低患者生存率同时可降低并发症,改善患者的生存质量。
Objective：To evaluate prognosis factors of primary vaginal cancer. Methods：Data of 80 patients who were hospitalized in the Department of Gynecology and Oncology of Guangxi Tumor Hospital from January 2003 to January 2015 were retrospectively ana-lyzed. All the patients were divided into radiotherapy group （n=49） and surpery group （n=31）. Based on radiation mode, the patients with radiotherapy were divided into two-dimensional radiotherapy group （n=29） and three-dimensional radiotherapy （3DRT） group （n=20）. Prognosis and complications between two subgroups were compared. Surgical patients were divided into laparoscopic surgery group （n=16） and laparotomy surgery group （n=15） with comparing therapeutic feasibility of video-laparoscopic operation and laparot-omy for primary vaginal carcinoma treatment. Results：Univariate analysis showed that FIGO stage, pathology, tumor size, and extent of vaginal mass involvement were related to prognosis （P〈0.05）. Multivariate analysis showed that FIGO stage and pathology were in-dependent prognostic factors. Statistical differences of 5-year survival were significant between 2DRT （20.9%） and 3DRT （58.6%） groups （P=0.022）. Incidences of urinary tract （14/29, 48.27%） and gastrointestinal symptoms （15/29, 51.72%） in 2DRT group and in 3DRT （3/20,15%;4/20,20%） are different significantly （P〈0.05）. Hospitalization days of laparotomy surgery group （57.00 ± 41.75） were significantly longer than that of laparoscopic surgery group （29.56 ± 7.30） （P=0.024）. Conclusion： Applying laparoscopic surgery and 3DRT improved quality of life without decreasing survival rate of patients with vaginal cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2017年第12期612-615,共4页
Chinese Journal of Clinical Oncology
关键词
原发性阴道癌
临床病理特征
治疗
预后
primary vaginal cancer
clinicopathological feature
treatment
prognosis
