摘要
目的探索转化生长因子TGF-β1 509T/C基因多态性与肝硬化的关系。方法计算机检索中国生物医学文献数据库、重庆维普中文科技期刊全文数据库、清华CNKI数据库、万方科技期刊全文数据库、PubMed,检索时间范围为建库到2017年3月。按纳入、排除标准选择TGF-β1 509位点基因多态性与肝硬化关系的病例对照研究。应用Stata 12.0软件对纳入的研究进行定量分析。结果共纳入10个病例对照研究,Meta分析结果显示509位点携带T等位基因的肝炎肝硬化合并OR=1.07,95%CI:0.81~1.41,显性基因模型分析(TT+CT vs CC)OR=1.08,95%CI:0.73~1.61,未发现显著发表偏倚。结论未发现TGF-β1 509T/C基因多态性与肝硬化有显著性关系。
Objective To evaluate the relationship between genetic polymorphism of transforming growth factor（TGF） β1 and sus- ceptibility of liver cirrhosis. Methods CBM,VIP, CNKI, Wanfang technological periodical full - text databases and Pubmed from set up to March, 2017 were electronically searched to identify case- control studies on the relationship between genetic polymorphism of TGF-β1 promoter 509 site, and liver cirrhosis. The data were quantitatively analyzed by Stata 12.0 software after assessing the quality of included studies. Results Ten case - control studies were selected for Meta - analysis based on our inclusion and exclusion standards. The results of Meta - analysis showed that the pooled OR value for liver cirrhosis with T allele of TGF - β1 gene at promoter 509 was 1.07 （95%CI： 0.81-1.41）, the pooled OR values of dominant gene model analysis （TT ＋ CTvsCC） werel.08 （95%CI： 0.73-1.61）. No significant publication bias was found. Conlcusion The genetic polymorphism of TGF -β1 at promoter 509 showed no association with susceptibility of liver cirrhosis.
作者
于海滨
丁惠国
Yu Haibin Ding Huiguo.(Department of Gastroenterology and Hepatology, Beijing Youan Hospital Affiliated to Capital Medical University, Beijing 100069, China)
出处
《医学研究杂志》
2017年第7期36-40,共5页
Journal of Medical Research
基金
国家自然科学基金资助项目(31400761)
北京市自然科学基金资助项目(7142079)
关键词
肝硬化
转化生长因子Β1
基因多态性遗传
META分析
Liver cirrhosis
Transforming growth factor betal
Genetic polymorphism
Enetic
Meta - analysis
