摘要
目的探讨老年干湿性型黄斑变性的光学相干断层扫描(OCT)特征。方法选取2012年5月至2015年12月在常州市第三人民医院诊治的老年性黄斑变性(AMD)患者120例(124只眼)进行黄斑OCT检查,其中湿性型62只眼(湿性型组),干性型62只眼(干性型组),同时选取同期接受检测的60只眼正常眼作为对照组。比较所有研究对象黄斑中心凹及距中心凹1 500μm处上、下、鼻、颞下视网膜全层厚度;比较所有研究对象距黄斑区中心凹6 mm处神经纤维层的厚度。结果湿性型AMD组中心凹、上方、下方、鼻侧、颞侧各厚度相较于正常组和干性型组显著增厚[(324±127)μm比(224±35)μm、(240±40)μm,(375±158)μm比(294±35)μm、(300±42)μm,(304±103)μm比(267±48)μm、(276±50)μm,(350±108)μm比(285±23)、(310±24)μm,(321±80)μm比(274±45)μm、(305±50)μm](P<0.05);干性型组中心凹、鼻侧及颞侧全层视网膜厚度相较于正常组增厚(P<0.05),上方和下方比较差异均无统计学意义(P>0.05)。湿性型AMD组的神经纤维层(MNFL)及黄斑视网膜神经上皮层(RNE)相较于正常组及干性型组明显增厚[(77.8±10.1)μm比(27.5±7.4)μm、(33.7±9.1)μm,(309±28)μm比(240±13)μm、(237±15)μm](P<0.05);干性型组的MNFL较正常组增厚(P<0.05),干性型组RNE与正常组比较差异无统计学意义(P>0.05)。结论 OCT可区别老年湿性型黄斑变性的全层视网膜、黄斑区及视网膜神经纤维厚度,能为AMD的诊断提供依据。
Objective To investigate the characteristics of optical coherence tomography（OCT） in aged patients with dry and wet macu[ar degeneration. Methods From May 2012 to Dec. 2015,120 age-related macular degeneration（AMD） patients （124 eyes） in Changzhou Third People＇s Hospital were selected. According to the type of macular degeneration, the patients were divided into a wet group（62 eyes） and a dry group（62 eyes） ,and 60 normal eyes were included as a control group. The full-thickness layers of each part of central fovea of macula and the upper, lower, nasal, and infratemporal thickness of the retina 1 500μm far from central fovea of macula of all the groups were compared. The nerve fiber layer thickness 6mm far from central fovea of macula of all the objects were compared. Results The thickness of the fovea centralis, above, bottom, nasal side and temporal sides of the wet group were significantly thicker than those of the normal group and the dry group [（324±127） μm vs（224±35） μm、（240±40） μm,（375±158） μm vs（294±35） μm、（300±42） μm,（304±103） μm vs（267±48） μm、（276±50） μm,（350±108） μm vs（285±23）、（310±24） μm,（321±80） μm vs（274±45） μm、（305±50） μm]（P〈0.05）; the thickness of the fovea, the nasal side and the temporal side of the dry group were thicker than those of the normal group （ P 〈 0. 05 ）, and there was no significant difference between the above and bottom levels（ P 〉 0.05 ）. The macular nerve fiber layer（MNFL） and retinal neuroepithelial layer（RNE） of the wet group were significantly higher than those of the normal group and the dry group [（77.8±10.1） μm vs（27.5±7.4） μm、（33.7±9.1） μm,（309±28） μm vs（240±13） μm、（237±15） μm]（P〈0.05）; the MNFL of the dry group was thicker than that of the normal group（ P 〈 0. 05 ） , and RNE had no statistically significant difference （ P 〉 0. 05 ）. Conclusion OCT can differentiate the thickness of the whole retina and the thickness of macular and retinal nerve fiber,and can be used as an effective tool to diagnosis of AMD.
出处
《医学综述》
2017年第14期2889-2892,共4页
Medical Recapitulate
基金
江苏省中医药局科技项目(LZ11125)
关键词
老年性黄斑变性
光学相干断层扫描
视网膜神经纤维层
Age-related macular degeneration
Optical coherence tomography
Retinal nerve fiber layer
