摘要
目的分析血管内导管相关性血流感染的临床分布特征及耐药性,指导血管内导管相关性血流感染的治疗。方法对医院确诊为血管内导管相关性血流感染的45例患者进行回顾性分析临床分布特征及其耐药性。结果 45例患者共检出47株病原菌,其中革兰阳性菌占38.29%,以葡萄球菌属为主,占25.53%,革兰阴性菌占34.04%,以不动杆菌属和肠杆菌科菌属为主,分别占12.76%和14.89%,真菌占27.66%;革兰阳性菌对替考拉宁和万古霉素耐药率均为0,对利福平和四环素耐药率为29.41%和47.06%;革兰阴性菌对阿米卡星和亚胺培南的耐药率为43.75%和37.50%;发现1株对氟康唑、伊曲康唑和伏立康唑耐药的热带念珠菌。结论了解血管内导管相关性血流感染临床分布特征及耐药性,有助于指导血管内导管相关性血流感染的治疗。
Objective To analyze the clinical distribution and drug resistance of pathogens of intravascular catheter-related bloodstream infections and to guide the treatment of intravascular catheter-related bloodstream infections. Methods A total of 45 patients with intravascular catheter-related bloodstream infections were analyzed retrospectively for clinical distribution and drug resistance. Results A total of 47 pathogens were detected in 45 patients, of which Gram-positive bacteria accounted for 38.29%, Staphylococci accounted for 25.53%, Gram-negative bacteria accounted for 34.04%, Acinetobacter and Enterobacteriaceae-based accounted for 12.76% and 14.89%, and fungi accounted for 27.66%. The resistant rates of Gram-positive bacteria to teicoplanin and vancomycin were 0, and that to rifampicin and tetracycline were 29.41% and 47.06%. The resistant rates of Gram-negative bacteria against amikacin, imipenem were 43.75% and 37.50%. A strain of Candida tropicalis resistant to fluconazole, itraconazole, and voriconazole was found. Conclusion To understand the clinical distribution and drug resistance of pathogens causing intravascular catheter-related bloodstream infections, it is helpful to guide the treatment of intravascular catheter-related bloodstream infections.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2017年第7期596-599,共4页
Chinese Journal of Antibiotics
基金
国家自然科学基金(No.81560701)
关键词
血管内导管相关性血流感染
病原菌
耐药
Intravascular catheter-related bloodstream infections
Pathogens
Resistance
