摘要
目的抗幽门螺杆菌(H.pylori)治疗对胆石症患者胆汁幽门螺杆菌脱氧核糖核酸(H.pylori DNA)及磷脂酶A2(PLA2)活性影响。方法收集我院胆石症行ERCP胆管取石+鼻胆管引流术(ENBD)或外科胆管取石行T管引流术患者60例(符合14C-尿素呼气试验阳性和胆汁H.pylori DNA阳性标准),随机分为两组,各30例。观察组患者给予四联疗法抗H.pylori治疗,对照组患者常规使用质子泵抑制剂治疗。比较两组H.pylori DNA阴转率及PLA2活性下降程度。结果观察组H.pylori DNA阴转率高于对照组(P<0.05)。两组引流第1天PLA2活性无明显差异;引流第8天PLA2活性均下降,且观察组抗H.pylori后PLA2活性显著低于对照组(P<0.01)。结论抗H.pylori治疗能提高胆石症患者胆汁H.pylori DNA阴转率,降低PLA2活性。
Objective To explore the effects of anti-H.pylori treatment to the negative conversion rate of H.pylori DNA and the activity of PLA2 in the bile of patients with gallstone. Methods Among the 60 patients with cholelithiasis undergoing ERCP bile duct lithotomy＋endoscopic nasobiliary drainage （ENBD）, or T tube drainage for surgical bile duct lithotomy, the patients who were positive for 14C breath test and biliary H.pylori DNA were randomly divided into two groups, 30 cases each. The treatment group（Group A） was treated with quadruple therapy of anti H.pylori, control group（group B） was treated with proton pump inhibitors;The nega-tive rate of H.pylori DNA and the decrease of PLA2 activity were compared between the two groups. Result The negative rate of H.pylori DNA in group A was higher than that in group B（P〈0.05）;there was no differ-ence in PLA2 activity before drainage in group A and group B on the first day of drainage. All the activity of PLA2 decreased at eighth days after drainage;but the activity of PLA2 in group A was lower than that in group B （P〈0.01）. Conclusion The Anti-H.pylori treatment can improve the H.pylori DNA negative conversion rate and decrease the activity of PLA2 in bile with cholelithiasis.
出处
《现代消化及介入诊疗》
2017年第3期322-324,共3页
Modern Interventional Diagnosis and Treatment in Gastroenterology
基金
韶关市科技计划(2014CX/K256)
