摘要
目的 分析中青年脂肪肝的患病特点以及影响其患病的危险因素,为中青年脂肪肝的预防和治疗提供理论依据.方法 选取2015年度年龄≤50岁的756例中青年健康体检者,经超声明确诊断为脂肪肝患者197例.分析不同特征中青年脂肪肝的患病情况,比较中青年脂肪肝与非脂肪肝组血液生化指标的差异,并应用二分类变量Logistic回归模型进行中青年脂肪肝危险因素分析.结果 中青年脂肪肝总患病率为26.1%（197/756）,其中男性为33.1%（119/359）,女性为19.6%（78/397）,男性患病率显著高于女性（χ2=17.833,P〈0.05）.随年龄增长脂肪肝患病率增高（χ2=33.296,P〈0.05）,40~50岁组脂肪肝患病率37.1%（111/299）与20岁~的15.0%（24/160）、30岁~的20.9%（62/297）比较显著升高;中青年脂肪肝患病影响因素Logistic回归模型分析结果显示,年龄、性别、BMI、饮酒、糖尿病史及FPG、TG、TC等生化指标与脂肪肝患病密切相关（P均〈0.05）;超重、肥胖、饮酒、糖尿病增加脂肪肝患病的危险性;生化指标中FPG、TG、TC脂肪肝组[（7.09±1.47） mmol/L、（5.98±1.23） mmol/L、（2.03±0.45） mmol/L]均高于非脂肪肝组[（5.14±1.71） mmol/L、（4.95±1.42 mmol/L、（1.23±0.67） mmol/L],差异均有统计学意义（t值分别为271.905,98.866,278.255,P均〈0.05）.结论 中青年脂肪肝的患病率较高,控制体质量,改掉饮酒嗜好,积极治疗糖尿病,降低机体血糖、血脂,可有效地减少中青年脂肪肝的患病率.
Objective To analyze the prevalence characteristics of fatty liver in young and middle-aged people,and to explore the risk factors of the disease,so as to provide clinical evidence for the prevention and treatment of fatty liver.Methods In 756 young and middle-aged healthy subjects with age≤50 years old,there were 197 fatty liver cases were diagnosed by ultrasonic test during 2015 year.The prevalence of different characteristics in young and middle-aged fatty liver was analyzed,the difference of blood biochemical index between fatty liver and non fatty liver group was compared,and risk factors of fatty liver was explored by binary logistic regression model.Results The total prevalence rate of fatty liver in young and middle-aged people was 26.1%（197/756）,among which 33.1% （119/359） were male and 19.6%（78/397） were female,the prevalence rate of male was significantly higher than that of female（χ2=17.833,P〈0.05）.The prevalence rate of fatty liver increased with age（χ2=33.296,P〈0.05）,which in 40-50 years old was 37.1%（111/299） and significantly higher than that in 20 years-（15.0%）（24/160） and 30 years-（20.9%）（62/297）.Logistic regression analysis on influencing factors of fatty liver prevalence showed that age,sex,body mass index（BMI）,drinking,diabetes and fasting blood glucose（FPG）,triglyceride（TG）,total cholesterol（TC） were closely related to fatty liver（P〈0.05）,overweight,obesity,drinking,diabetes increased the risk of fatty liver disease.Biochemical indicators（FPG,TG,TC） in fatty liver group were higher than those in non fatty liver group（（7.09±1.47） mmol/L vs.（5.14±1.71） mmol/L,（5.98±1.23） mmol/L vs.（4.95±1.42） mmol/L,（2.03±0.45） mmol/L vs.（1.23±0.67） mmol/L,t=271.905,98.866,278.255;P〈0.05）.Conclusion The prevalence rate of fatty liver in young and middle-aged people is high,and controlling body weight,give up drinking,active treating diabetes,reducing blood glucose and blood lipids can effectively decrease the prevalence of fatty liver in young and middle-aged people.
作者
康世锐
闫宇
刘芳
武晓猛
肖倩
肖永红
Kang Shirui Yan Yu Liu Fang Wu Xiaomeng Xiao Qian Xiao Yonghong(Oncology Department, the Third Hospital of Tangshan, Tangshan 063100, China)
出处
《中国综合临床》
2017年第4期296-300,共5页
Clinical Medicine of China
基金
河北省教育厅高等学校科学技术研究项目（ZD2015039）
关键词
中青年
脂肪肝
患病特点
危险因素
LOGISTIC回归模型
Young and middle-aged people
Fatty liver
Prevalence characteristic
Risk factors
Logistic regression model
