摘要
自噬是一种降解病原体和相关细胞器尤其是损伤的线粒体的分子机制,自噬也可清除其他的细胞成分,例如炎症和细胞因子,这为抗炎症提供了重要的途径.相关研究发现,自噬的产生或降解能够影响动脉粥样硬化斑块的发展过程.因此,在疾病出现时,自噬的调节对于疾病治疗的靶点具有重要的意义.然而,在正常情况和炎症反应时,自噬的调节方式是多方面的.这些错综复杂的改变是通过炎症和环境刺激所产生的,这对于了解和揭示自噬调节的炎症和提供相应的治疗方案是必不可少的.因而人了解自噬的分子机制,以及血管内皮细胞、血管平滑肌细胞、巨噬细胞自噬在动脉粥样硬化中起到的作用对于疾病的发展和靶向治疗具有重要意义.
Autophagy is a molecular mechanism for the degradation of pathogens and organelles,especially the damaged mitochondria.Autophagy also clears other cellular components,and provides an important way to regulate inflammation.Studies have found that autophagy can affect the development of atherosclerotic plaque.However,in normal circumstances and the inflammatory response,the regulation of autophagy is multifaceted.Understanding these complex changes of autophagy induced by inflammation and environmental stimuli are essential for the treatment of inflammation.To understand the molecular mechanisms of autophagy,and the role of vascular endothelial cells,vascular smooth muscle cells and macrophages in atherosclerosis is of great significance for the development of targeted therapy for atherosclerosis.
出处
《国际免疫学杂志》
CAS
2017年第3期309-312,共4页
International Journal of Immunology
基金
国家自然科学基金（81541031）
