摘要
目的探讨静脉水化对冠状动脉介入术后对比剂肾病的预防价值。方法选取2013年6月至2015年12月云浮市人民医院收治的拟行经皮冠状动脉介入治疗的80例冠心病患者,随机分为研究组(40例)与对照组(40例)。对照组行常规治疗,研究组行静脉水化治疗。术后24 h对其血清肌酐、胱抑素C水平进行测定,对比两组以血清肌酐和以胱抑素C为基准的对比剂肾病发病率。根据有无对比剂肾病发生将患者分为对比剂肾病组(发生对比剂肾病)和非对比剂肾病组(未发生对比剂肾病),比较两组患者临床资料并分析对比剂肾病发病的危险因素。结果研究组以肌酐为基准的对比剂肾病发病率和以胱抑素C为基准的对比剂肾病发病率均低于对照组(分别为5.0%比25.0%和10.0%比37.5%),差异均有统计学意义(P<0.05);对比剂肾病组年龄、吸烟量、对比剂量及液体入量水平与非对比剂肾病组相比,差异有统计学意义(P<0.05)。结论对于行冠状动脉介入术治疗的冠心病患者,术后采用静脉水化,可降低术后对比剂肾病发病率,且年龄、吸烟量、对比剂量及液体入量均与对比剂肾病的发病率具有一定相关性。
Objective To explore the application value of intravenous hydration treatment for the prevention of contrast - induced nephropathy after percutaneous coronary intervention. Methods 80 patients who were diagnosed as coronary heart disease and received percutaneous coronary intervention in Yunfu People＇ s Hospital from June of 2013 to December of 2015 were randomly devided into study group and control group, 40 cases in each group. The control group received routine treatment, and the study group received intravenous hydration treatment. Serum creatinine, cystatin C and serum creatinine levels were measured at 24 h postoperatively, the incidences of contrast - induced nephropathy were compared between the two groups based on serum creatinine and cystatin - C levels, and the risk factors of contrast - induced nephropathy were analyzed. Results The incidence rates of creatinine - based contrast - induced nephropathy in study group and control group were 5.0% and 25.0% respectively; the incidence of contrast- induced nephropathy based on cystatin C was 10. 0% in the study group and 37.5% in the control group, and the difference was statistically significant （P 〈 0. 05）. There were significant differences in age, consumption of cigarettes, contrast dose and fluid intake levels between contrast - induced nephropathy group and non - contrast - induced nephropathy group （ P 〈 0. 05 ）. Conclusion For coronary heart disease patients who underwent percutaneous coronary intervention, intravenous hydration treatment can reduce the incidence of postoperative contrast- induced nephropathy. Age, consumption of cigarettes, contrast dose and fluid intake are correlated with the incidence of contrast nephropathy.
出处
《河南医学研究》
CAS
2017年第13期2308-2310,共3页
Henan Medical Research
关键词
静脉水化
冠状动脉介入术
对比剂肾病
intravenous hydration treatment
coronary interventional procedures
contrast -induced nephropathy
