摘要
近年来,高氟对中枢神经系统的损伤越来越引起广泛关注,但其作用机制还不完全清楚。该文探讨了氟对中枢神经系统损伤的可能机制,包括氟中毒对中枢神经系统造成氧化应激、炎性损伤,对神经递质分泌及其受体、脑内蛋白质组成及含量的影响,对信号传导通路的干扰等,为进一步开展氟对中枢神经系统损伤机制的研究提供依据。
In recent years,central nervous system(CNS) injuries induced by excessive fluoride exposure have raised more and more concern,but it is not clear for the mechanism of injuries.This review discussed the possible mechanisms from several aspects,including fluoride-induced oxidative stress and inflammatory injury in CNS,the effect on neurotransmitter secretion and its receptors,proteome of brain and disturbance on signal transduction pathways caused by fluorosis,and provides literature basis for the further studies on mechanisms of CNS injury induced by excessive fluoride exposure.
出处
《环境与健康杂志》
CAS
北大核心
2016年第4期368-371,共4页
Journal of Environment and Health
基金
教育部博士点专项基金(20112104110021)
辽宁省大学生创新训练项目乙类(2015049)
关键词
氟
中枢神经系统
氧化应激
Fluoride
Central nervous system(CNS)
Oxidative stress
