摘要
目的 探讨人工肝联合结肠灌洗、大黄煎剂结肠透析治疗重症肝炎的治疗效果.方法 选择2013年5月至2015年4月我院收治的重症肝炎患者127例,采用随机数字表法将患者分为常规组42例、人工肝组42例和观察组43例.常规组采用常规内科治疗,人工肝组在常规组基础上加人工肝治疗,观察组在人工肝组基础上加结肠灌洗、大黄煎剂结肠透析治疗.比较三组治疗前、后肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）、内毒素（LPS）及丙氨酸氨基转移酶（ALT）、总胆红素（STB）、清蛋白（ALB）水平.结果 治疗后,人工肝组、观察组血清TNF-α、IL-6、LPS明显低于常规组（P〈0.05）,观察组血清TNF-α、IL-6、LPS明显低于人工肝组（P〈0.05）;人工肝组、观察组血清ALT、STB明显低于常规组（P〈0.05）,观察组血清ALT、STB明显低于人工肝组（P〈0.05）;观察组血清ALB水平明显高于常规组和人工肝组（P〈0.05）.结论 人工肝联合结肠灌洗、大黄煎剂结肠透析治疗可有效抑制重症肝炎患者炎性细胞因子的释放,纠正炎症反应状态,保护肝功能,改善患者预后,值得临床推广应用.
Objective To investigate the effect of artificial liver combined with colon lavage and rhubarb decoction of colon dialysis in the treatment of patients with severe hepatitis. Methods From May 2013 to March 2015, 127 cases of patients with severe hepatitis in our hospital were selected and randomly divided into routine group （n=42）, artificial liver group （n=42） and observation group （n=43） according to random number table method. The routine group was given routine medical treatment, the artificial liver group was treated with artificial liver on the basis of routine group, while the observation group was treated with colon lavage and rhubarb decoction on the basis of artificial liver group. The serum levels of tumor necrosis factor-α （TNF-α, interleukin-6 （IL-6）, endotoxin （LPS）, alanine aminotransferase （ALT）, total bilirubin （STB）, and albumin （ALB） between the three groups were compared. Results After treatment, the serum levels of TNF-α, IL-6 and LPS of the artificial liver group and the observation group were significantly lower than those of the routine group （P〈0.05）, the serum levels of TNF-α, IL-6 and LPS of the observation group of were significantly lower than those of the artificial liver group （P〈0.05）. The serum levels of ALT and STB of the artificial liver group and the observation group were significantly lower than those of the routine group （P〈0.05）, the serum levels of ALT and STB of the observation group were significantly lower than those of the artificial liver group （P〈0.05）; the serum level of ALB of the observation group was significantly higher than that of the routine group and artificial liver group （P〈0.05）. Conclusion Artificial liver combined with colon lavage and rhubarb decoction of colon dialysis in the treatment of patients with severe hepatitis can inhibit the release of inflammatory cytokines, correct the inflammatory state and protect the liver function, improve the prognosis of patients, it is worthy of clinical application.
出处
《临床研究》
2017年第5期168-170,共3页
Clinical Research
关键词
人工肝
结肠灌洗
大黄
重症肝炎
artificial liver
colonic lavage
rhubarb
severe hepatitis
