摘要
目的:探讨华蟾素对原发性肝癌骨转移继发骨侵蚀破坏患者疼痛缓解率的影响,观察华蟾素作用后患者血清骨桥蛋白(OPN)、基质金属蛋白酶-9(MMP-9)表达的变化。方法:选取2015年12月~2017年03月广西中医药大学附属瑞康医院收住的原发性肝癌骨转移继发骨侵蚀破坏患者60例,随机分为观察组35例和对照组25例,对照组采用射频消融、局部放疗联合唑来膦酸治疗,观察组加用华蟾素注射液。比较两组疼痛缓解率,检测两组治疗前、治疗后4、8、12w血清OPN、MMP-9水平,并分析相关性。结果:治疗后8、12w,观察组疼痛缓解率分别为82.86%、94.29%,对照的分别为48.00%、52.00%(P﹤0.05);两组治疗后4w、8w、12w与治疗前比较,OPN、MMP-9水平均降低(P﹤0.05),观察组治疗后OPN、MMP-9水平均显著低于对照组同期水平(P﹤0.05);观察组35例治疗后患者疼痛缓解率与外周血清OPN、MMP-9浓度水平呈显著负相关(r=-0.994、-0.999,P﹤0.05)。结论华蟾素注射液对于原发性肝癌骨转移继发骨侵蚀破坏患者有明显的镇痛作用,可以显著降低患者血清OPN、MMP-9的浓度水平,可能通过抑制OPN、MMP-9的表达发挥镇痛作用。
Objective：To explore the effect of cinobufacin on rate of pain relief in hepatocellular carcinoma patients with bone metastases seconda-ry to bone erosion,and to observe the changes of osteopontin （OPN）,matrix metalloproteinases-9（MMP-9） expression in serum of these patie-nts after using cinobufacin injection.Methods：60 cases of hepatocellular carcinoma patients with bone metastases secondary to bone erosion who were admitted into the Ruikang hospital affiliated to guangxi university of Chinese medicine flora December 2015 to March 2017 were randomlydivided into control group 25 cases and observation group 35cases.The control group received radiofrequency ablation,local radiotherapy combi-ined with zoledronic acid treatment,and the observation group received cinobufacin injection on the basis of the control group.The rate of pain relief was compared,and the serum levels of OPN,MMP-9 were detected before treatment,4 weeks,8 weeks and 12 weeks after treatment,then the correlations were analyzed.Results：After 8,12 weeks treatment,the rate of pain relief in the the observation group was 82.86%,82.86%,and the control group was 48.00%,52.00%,respectively （P 〈 0.05）.The OPN,MMP-9 levels after 4 weeks,8weeks and 12 weeks were lower than those before treatment in control group and observation group.The serum OPN,MMP-9 levels in observation group were significantly lower than those in control group after treatment （P 〈 0.05）.There existed significant negativecorrelation between the rate of pain relief and serum OPN,MMP-9 conc-entration levels in 35cases of observation group patents after treatment （r =-0.994, -0.999,P 〈 0.05）.Conclusion：As to hepatocellular carcinoma patients with bone metastases secondary to bone erosion,cinobufacin injection not only has obvious analgesic curative effect,but also couldsignificantly reduce the serum OPN,MMP-9 levels.Cinobufacin injecti-on may play an analgesic curative effect by inhibiting the exvression of OPN and MMP-9.
出处
《大众科技》
2017年第6期95-97,114,共4页
Popular Science & Technology
基金
国家自然科学基金资助项目(81473532)
广西中医药大学硕士研究生科研创新项目(YJS201652)
关键词
华蟾素
原发性肝癌
骨转移
疼痛缓解率
骨桥蛋白
基质金属蛋白酶-9
Cinobufacin
hepatocellular carcinoma
bone metastases
rate of pain relief
osteopontin
matrix metalloproteinases-9
