摘要
目的研究超滤腹水回输对肝硬化腹水患者肾血管调节因子及RAAS系统的影响。方法随机选择我院2010年1月至2012年6月肝硬化顽固性腹水住院患者50例,并给予超滤腹水回输治疗,比较治疗前、后内毒素、血栓素、白三烯、肾素及醛固酮水平。结果治疗后,患者内毒素、血栓素及白三烯水平均下降,差异有统计学意义(P<0.05);患者肾素及醛固酮水平均下降,差异有统计学意义(P<0.05)。结论超滤腹水回输可减低肾血管调节因子活性,并抑制RAAS系统,提示该方法可能通过抑制肾脏血管活性因子活性,改善肾血流作用,进而抑制RAAS系统激活,为超滤腹水回输提供理论依据。
Objective To observe the impact of ascites ultrafiltration back-transfusion on renal vascular regulation factor and RAAS system in cirrhotic ascites. Methods Fifty cases of hospitalized patients with intractable ascites of cirrhosis from January 2010 to June 2012 were randomly selected and given ascites uhrafihration back-transfusion therapy. The levels of endotoxin, thromboxane, leukotriene, renin and aldosterone were compared before and after treatment. Results After treatment, the levels of endotoxin, thromboxane and leukotriene of patients decreased （P〈0.05）. The levels of renin and aldosterone of patients decreased （P〈0.05）. Conclusion Ascites uhrafihration back-transfusion can reduce the activity of renal vascular regulation factor and inhibit RAAS system. It shows that this therapy may inhibit the activity of renal vas- cular regulation factor, improve the renal blood flow, then inhibit the activity of RAAS system, which provides the theoreti- cal basis for the ascites ultrafihration back-transfusion.
出处
《临床医学研究与实践》
2017年第19期37-38,共2页
Clinical Research and Practice
基金
2010年西安市卫生局科研项目(No.J2010B22)
关键词
肝硬化
腹水
超滤回输
肾血管调节因子
liver cirrhosis
ascites
ultrafiltration back-transfusion
renal vascular regulation factor
