摘要
目的近年来,冲击波疗法因其无创、副作用少的特点而在治疗方面的应用愈加受到关注。本文探究体外冲击波疗法治疗骨关节和肌肉疼痛性疾病的机制,各炎症因子在治疗过程中的变化与作用。方法采用随机对照试验实验的方法,将40只雄性SD大鼠随机分为正常对照组、模型对照组、实验组1、实验组2,每组10只,通过比较各组间炎症消退时间、肿胀程度、血清中炎性因子含量、组织切片中的炎症细胞的差异以研究冲击波在消炎、镇痛中的作用机制。结果冲击波疗法能明显缓解炎症局部红肿,减轻炎症渗出和炎症细胞浸润,对局部组织无明显损伤。其治疗作用可能与组织中抗炎镇痛因子含量上升,致炎性因子含量下降有关。结论冲击波处理有明显减轻局部炎症反应,加速炎症的吸收消散效应,从而改善症状,减轻疼痛。其机制与促进β-内啡肽产生,抑制前列腺素E2(prostaglandin E2,PGE2)、5-羟色胺等疼痛因子释放有关。一氧化碳在冲击波的治疗中也发挥重要调节作用,但其作用方式尚不明确。
Objective In recent years,attention to non-invasive shock wave therapy which characteristic of fewer side effects and its application in the treatment has increased,this paper intends to explores the mechanisms of extracorporeal shock wave therapy for bone and joint and muscle pain;the function and transformation of Inflammatory during treatment.Methods Forty male Sprague-Dawley rats were randomly divided into normal control group,model control group,experimental group 1 and experimental group 2,10 rats in each group.By comparing the time of inflammation resolution and swelling extent,serum levels of inflammatory factors,inflammatory cells in tissue sections to study the mechanism of shock wave in anti-inflammatory and analgesia.Results The shock wave therapy could alleviate local inflammation,alleviate inflammatory exudation and infiltration of inflammatory cells,improve symptoms,relieve pain,and do no obvious damage to local tissue.It may be related to the increase of anti-inflammatory analgesic factor and the decrease of Inflammatory factor.Conclusion Extracorporeal shock wave therapy alleviate local inflammation and accelerate the dissipation of inflammation which improve symptoms,reduce pain.The mechanism may be related to promote β-endorphin production,inhibition of PGE2,5-HT and other pain factor release and Nitric oxide is also play an important regulatory role in therapy,but it＇s mode of action is not clear.
出处
《实用骨科杂志》
2017年第7期618-621,625,共5页
Journal of Practical Orthopaedics
基金
同济大学人才基金(2014KJ091)
关键词
体外冲击波
炎症
镇痛
抗炎
随机对照实验
extracorporeal shock wave
inflammation
analgesia
anti-inflammatory
randomized controlled trial
