摘要
目的探讨青年、中老年乳腺癌患者的临床病理特征。方法选取我院2011年1月至2014年12月确诊的50例青年乳腺癌患者(年龄≤35岁,青年组),并抽取同期中老年乳腺癌患者(年龄>35岁,中老年组)560例,对两组患者的临床病理学特征(病理类型、组织学分级、瘤体最大径、淋巴结转移情况、免疫组化结果等)进行回顾性分析。结果青年组的淋巴结转移率高于中老年组(68%VS56.8%),差异有统计学意义(P<0.05)。青年组VS中老年组在ER、HER-2、Ki-67的阳性率分别为52%vs67.3%、72%vs49.6%、74%vs56.4%,前者的ER阳性率低于后者,在HER-2、Ki67阳性率方面则高于后者,且差异有统计学意义(P<0.05)。两组患者在组织学分级、瘤体最大径、病理类型、PR及P53的表达上差异无统计学意义(P>0.05)。结论青年乳腺癌具有更强的侵袭性,更易发生转移,可能与青年组ER阳性率较低、HER-2阳性率较高等因素有关。因此乳腺检查应纳入常规体检,做到早发现,早诊断,早治疗。
Objective To investigate the clinical pathological characteristics of young and middle-aged and elderly pa- tients with breast cancer. Methods 50 cases of young patients with breast cancer confirmed in the Affiliated Hospital of Southwest Medical University between January 2011 and December 2014 were selected（ age 〈 35 ,young group）. Meanwhile,560 middle-aged and elderly patients with breast cancer （aged 35, middle aged and elderly group）were selected. The clinicopathological features （pathological type, histological grade, maximum diameter of the tumor, condition of lymph node metastasis, results of immunohisto- chemistry, etc. ）of the two groups were analyzed retrospectively. Results The lymph node metastasis rate of the young group was higher than that of the middle and old age group（68% VS56. 8% ） ,and the difference was statistically significant（P 〈 0.05）. The positive rate of ER, HER-2, Ki-67 in young group and the old group were 52% VS67. 3%, 72% VS49. 6%, 74% VS56. 4%. The positive rate of ER in the former was lower than that in the latter, and the difference was statistically significant（ P 〈 0.05 ）, but the positive rate of HER-2 and Ki67 in the former were higher than those in the latter（P 〈 0. 05）. There was no significant difference between the two groups in histological grading, maximum diameter of tumor, pathological type, expression of PR and P53 （P 〉 0.05 ）. Conclusion Young breast cancer is more aggressive and more prone to metastasis,which may be related to higher ER pos- itive rate and higher positive rate of HER-2 in young group. Therefore, the breast examination should be included in routine physi- cal examination, so as to achieve early detection, early diagnosis and early treatment.
出处
《四川医学》
CAS
2017年第7期753-756,共4页
Sichuan Medical Journal
基金
2015年泸州市人民政府-四川医科大学科技战略合作项目(编号:2015LZCYD-S02)
关键词
乳腺癌
青年
中老年
病理
临床特征
breast cancer
youth
middle-aged and elderly
pathology
clinicalcharacteristics
