摘要
目的系统综述各地使用低剂量CT筛查肺癌的实践情况。方法根据纳入与排出标准,从中英文相关数据库筛选出的36项筛查项目进行系统性分析。并且通过Meta分析计算肺癌检出率及95%置信区间,绘制森林图。结果基线筛查的肺癌检出率为0.9%,定期筛查的肺癌发现率为0.5%,总体肺癌筛查发现率为1.3%(1.0%~1.7%);检出的肺癌病理分型以腺癌为主(52%),分期以Ⅰ期非小细胞肺癌为主(70.8%)。结论在我国医疗资源相对不足的情况下,推广低剂量CT的肺癌筛查,值得深入研究和思考。
Objective To systematically review the worldwide experiences of lung cancer screening using low-dose CT. Methods 36 projects were selected from the national and international databases according to the inclusion and exclusion criteria and were reviewed systematically. Overall detection rate and its 95% CI were calculated and forest plot was drawn by meta-analy- sis. Results Baseline prevalence rate of lung cancer was 0.9%. The incident rate of annual repeated screening for lung cancer was 0.5%. The overall detection rate was 1.3%. Of the 1946 cases with histopathological diagnosis ,52% were adenocarcinoma. 70.8% were defined as stage I NSCLC. Conclusion Given that the medical resources are relatively insufficient in our country, it needs further study and ethical concerns to apply low-dose CT screening to the communities.
出处
《实用癌症杂志》
2017年第8期1283-1287,共5页
The Practical Journal of Cancer
关键词
肺肿瘤
低剂量CT
筛查
Lung neoplasms
Low-dose CT
Screening
