摘要
目的检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并变应性鼻炎(AR)的儿童的细胞免疫及体液免疫功能,分析AR对OSAHS患儿免疫功能的影响。方法收集51例OSAHS患儿,按照是否合并AR分为OSAHS合并AR组(OSA+AR组)和单纯OSAHS组(OSA组)两组,其中OSA+AR组根据AR程度又分为轻、中、重三个亚组。检测各组患儿的体液免疫与细胞免疫指标,分析两组组间及OSA+AR组组内免疫功能的差异。结果与正常值相比,两组患儿CD3+T细胞、CD4+T细胞及CD4+/CD8+比值均显著降低,IgG、IgA、IgM含量均显著升高,差异有统计学意义(P<0.05)。两组患儿组间相比:OSA+AR组患儿IgA含量、IgE含量比OSA组高,差异有统计学意义(P<0.05)。随着合并AR患儿的过敏程度加重,CD8+T细胞所占比例逐渐升高,且轻度组与中、重度组相比,差异均有显著性意义(P<0.05);CD4+/CD8+比值逐渐降低,且轻度组与重度组相比,差异有显著性意义(P<0.05);CD4+T细胞所占比例、IgA含量有降低趋势,IgE含量有升高趋势,但无显著统计学意义(P>0.05)。结论 OSAHS患儿的细胞免疫及体液免疫功能均有一定程度下降,其中合并AR的患儿免疫功能下降更明显,AR在OSAHS患儿的免疫功能下降中发挥重要作用。
Objective To detect the humoral and cellular immune function in children with obstructive sleep apnea hypopnea syndrome （OSAHS） complicated with allergic rhinitis （AR）,and analyze the effect of AR on the immune function in children with OSAHS. Methods 51 children with OSAHS were collected and divided into two groups： OSAHS complicating AR group （OSA＋AR group） and pure OSAHS group （OSA group）.And the OSA＋AR group was divided into light, moderate, heavy subgroups according to the degree of AR. The humoral immune and cellular immune indexex of all cases were detected, and the differences of the immune function between the two groups and within the three subgroups were analyzed. Results When comparing with the normal value, the content of IgG、IgA and IgM increased obviously and the percentage of the CD3＋T lymphocytes、the CD4＋T lymphocytes and the CD4＋/CD8＋ radiodecreased significantly in the two groups, and the difference was significant （P〈0.05）.The content of IgA and IgEin the OSA＋AR group was higher than that in the OSA group,and the difference was significant （P〈0.05）. With the aggravation of AR, the CD8＋T lymphocytes percentage increased ,and the difference between the light subgroup and the moderate, heavy subgroups was significant （P〈0.05）; and the CD4＋/CD8＋ radio decreased with a significant difference between the light subgroup and the heavy subgroup（P〈0.05）. In addition, the percentage of CD4＋T lymphocytes and the level of IgA had a tendency to decrease,and the level of IgE had a tendency toincrease, but the difference was not significant （P〉0.05）. Conclusions The humoral and cellular immune function decreases in children with OSAHS, and if AR is complicated, the decrease is more obvious. AR plays an important role in the decrease ofimmune function in children with OSAHS.
出处
《中国中西医结合耳鼻咽喉科杂志》
2017年第3期225-229,共5页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
基金
上海市自然科学基金项目(编号:12411952407)
