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某院大肠埃希菌的耐药性分析 被引量:1

Drug resistance and distribution of Escherichia coli in a hospital
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摘要 目的动态监测院内分离大肠埃希菌的耐药性及分布,为临床经验用药及控制感染提供理论依据。方法采用WHONET 5.6对2015年1月1日~2015年3月31日本院临床分离的224株大肠埃希菌对临床常用的19种抗菌药物的耐药性及分布进行分析。结果分离的224株大肠埃希菌对氨苄西林、头孢唑啉、环丙沙星、头孢呋辛、左氧氟沙星、头孢噻肟、庆大霉素、氨曲南、头孢吡肟、妥布霉素、头孢他啶、阿莫西林/克拉维酸、头孢西丁、头孢哌酮/舒巴坦、阿米卡星、哌拉西林/他唑巴坦、厄他培南、美罗培南和亚胺培南的耐药率分别为84.4%(189株)、60.3%(135株)、57.1%(128株)、57.1%(128株)、53.1%(119株)、52.7%(118株)、45.1%(101株)、42.0%(94株)、41.1%(92株)、37.1%(83株)、26.3%(59株)、15.2%(34株)、12.1%(27株)、6.7%(15株)、4.0%(9株)、4.0%(9株)、1.3%(3株)、1.3%(3株)和1.3%(3株)。59.4%(133株)的标本来源于尿液,17.0%(38株)的标本来源于痰液;26.8%(60株)的标本分布在泌尿内科病房。结论本院已发现对碳青霉烯类抗菌药物耐药的大肠埃希菌,临床应动态监测大肠埃希菌的耐药性及分布,以提高经验用药的准确率。 Objective To investigate the drug-resistance and distribution of isolated Escherichia coli dynamically, and to provide evidence to improve the clinical experience of drug application and infections control measures. Methods Total of 224 stains of Escherichia eoli were collected from January 1 st, 2015 to March 31 st, 2015, whose drug-resistance to 19 antibacterials and the clinical distribution were analyzed by WHONET 5.6. Results Drug-resistance rates of 224 stains of Escherichia coli to ampicillin, cefazolin, ciprofloxacin, cefuroxime, levofloxacin, cefotaxime, gentamicin, aztreonam, cefepime, tobramycin, ceftazidime, amoxicillin/clavulanate, cefoxitin, cefoperazone/sulbactam, amikacin, piperacillin/tazobactam, ertapenem, meropenem and imipenem were 84.4% (189 strains), 60.3% (135 strains), 57.1% (128 strains), 57.1% (128 strains), 53.1% (119 strains), 52.7% (118 strains), 45.1% (101 strains), 42.0% (94 strains), 41.1% (92 strains), 37.1% (83 strains), 26.3% (59 strains), 15.2% (34 strains), 12.1% (27 strains), 6.7% (15 strains), 4.0% (9 strains), 4.0% (9 strains), 1.3% (3 strains), 1.3% (3 strains) and 1.3% (3 strains). About 59.4% (133 strains) Escherichia coli were collected from urine specimens, and 17.0% (38 strains) were from sputum specimens; 26.8% (60 strains) were distributed in Urinary Department of Internal Medicine Ward. Conclusions Carbapenem-resistant Escherichia coli has been found in our hospital. Dynamic monitoring of the drug-resistance and distribution of the Escherichia coli could improve the accuracy of empirical medication.
出处 《中华实验和临床感染病杂志(电子版)》 CAS 2017年第3期306-309,共4页 Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
基金 山东省自然科学基金(No.ZR2013HM009)
关键词 大肠埃希菌 耐药性 标本分布 Escherichiacoli Drug-resistance Specimen distribution
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