摘要
目的观察反流性胃炎行舒必利联合质子泵抑制剂(PPT)、黏膜保护剂治疗的疗效。方法选取178例反流性胃炎患者临床资料,将其分为对照组(89例)、观察组(89例),对照组给予吗丁啉、PPI、黏膜保护剂联合治疗,观察组给予以舒必利、PPI联合黏膜保护剂治疗,观察比较两组临床症状、治疗时间及不良反应情况。结果两组治疗后各症状积分均较治疗前下降,其中,观察组治疗后食管反流、腹胀、烧心感症状积分(0.65±0.32)分、(0.41±0.24)分、(0.37±0.19)分均较对照组积分(1.42±0.87)分、(1.27±0.76)分、(1.15±0.69)分低,差异具有统计学意义(P<0.05);观察组胆汁反流时间(6.31±2.87)d、黏膜损伤时间(8.15±3.09)d及腹痛时间(7.31±2.95)d均较对照组各项时间短(P<0.05);且观察组不良反应率8.99%明显低于对照组反应率20.22%,差异具有统计学意义(P<0.05)。结论舒必利、PPI及黏膜保护剂联合治疗反流性胃炎可有效减轻患者临床症状,加快患者病情治疗时间,且不良反应少,安全性高。
Objective To observe the flow line gastritis sulpiride combined proton pump inhibitors （PPT）, the therapeutic effect of mucous mem± brane protective agent. Methods To select 178 cases of reflux gastritis patients clinical data, it can be divided into the control group （89 cases）, the observation group （89 cases） and control group given PPI, mucosal protective agent, with the combination therapy, observation group was given with sulpiride joint mucosa protectant, PPI therapy, compare two groups of clinical symptoms, treatment time and adverse reactions. Results The two groups after treatment the symptoms integral was decreased, the among them, the observation group after treatment esophageal reflux, bloating, heartburn symptoms （0.65 ± 0.32） points, （0.41 4± 0.24） points, （0.37 ± 0.19） points than the control group （1.42 ± 0.87） points, （1.27 ± 0.76） points, low （1.15 ± 0.69） points, statistically significant difference （P〈0.05）; Observation group of bile reflux time （6.31 ± 2.87）d, mucosal injury time （8.15 ± 3.09）d and time （7.31 ± 2.95）d abdominal pain control group all the time is short （P〈0.05）; Adverse reaction rate was 8.99% and observation group was obviously lower than control group in response rate was 20.22%, statistically significant difference （P〈0.05）. Conclusion Sulpiride, PPI and mucosa protectant combined treatment reflux gastritis patients can effectively reduce the clinical symptoms, speed up the patients, treatment time and less adverse reaction, high safety. Key words： Reflux gastritis; Sulpiride; Proton pump inhibitor; Mucous membrane protective agent; The curative effect
出处
《当代医学》
2017年第22期15-18,共4页
Contemporary Medicine
关键词
反流性胃炎
舒必利
质子泵抑制剂
黏膜保护剂
疗效
Reflux gastritis
Sulpiride
Proton pump inhibitor
Mucous membrane protective agent
The curative effect
