摘要
目的:探讨白细胞介素-2(IL-2)、γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)在膀胱癌患者中的水平变化及意义。方法:选择从2015年2月到2016年12月在我院进行治疗的膀胱癌患者66例纳入本次研究,为膀胱癌组,选择同期在我院治疗的65例腺性膀胱炎患者记为膀胱炎组,另选择同期在我院进行体检的健康体检者65例记为对照组,对比各组患者的IL-2、IFN-γ及TNF-α水平,不同类型和临床分期的膀胱癌患者的IL-2、IFN-γ及TNF-α水平,分析IL-2、IFN-γ及TNF-α水平与其病理类型和临床分期的相关性。结果:膀胱癌组的IL-2和IFN-γ水平均明显低于膀胱炎组和对照组,TNF-α水平明显高于膀胱炎组和对照组,差异均有统计学意义(均P<0.05)。不同类型膀胱癌患者的IL-2、IFN-γ及TNF-α水平相比,差异均无统计学意义(均P>0.05)。T2~T4膀胱癌患者的IL-2、IFN-γ水平均明显低于Tis^T1者,TNF-α水平明显高于Tis^T1者,差异均有统计学意义(均P<0.05)。根据Spearman相关性分析发现,膀胱癌患者的IL-2、IFN-γ与其临床分期均呈负相关(P<0.05),TNF-α与其临床分期呈正相关(P<0.05),而患者的IL-2、IFN-γ及TNF-α水平与其病理类型则无明显相关性(P>0.05)。结论:IL-2、IFN-γ在膀胱癌患者中的表达明显下降,而TNF-α表达明显上升,且患者的上述三种指标与其临床分期有关,但与其病理类型无关。
Objective： To discuss the level changes and significance of IL-2, IFN-3,, TNF-α in patients with bladder cancer. Methods： 66 patients with bladder cancer who were treated in our hospital from February 2015 to December 2016 were enrolled in this study, which was denoted by bladder cancer group, 65 patients with cystitis glandularis who were treated in our hospital during the same period were selected as cystitis group, another 65 healthy persons who were examined in our hospital during the same period were selected as control group, and compared the levels of IL-2, IFN-γand TNF-α in each group, and the levels of IL-2, IFN-γ and TNF-α in patients with bladder cancer of different types and clinical stages. The correlation of IL-2, IFN-γ and TNF-α levels with pathological types and clinical stages were analyzed. Results： The levels oflL-2 and INF-γ in bladder cancer group were significantly lower than those in cystitis group and control group, the level of TNF-α was significantly higher than that of cystitis group and control group, the difference was statistically significant （P〈0.05）. There was no significant difference in IL-2, IFN-γ and TNF-α levels in different types of bladder cancer patients （both P〉0.05）. IL-2, IFN-γ levels in T2 to T4 bladder cancer patients were significantly lower than Tis to T1, TNF-α level was significantly higher than Tis to T1, the difference was statistically significant （both P〈0.05）. According to Spearman method evaluation correlation founded that IL-2, IFN-~/levels in patients with bladder cancer were negatively correlated with clinical stage, TNF-α level was positively correlated with clinical stage. However, there was no correlation between IL-2, IFN-γ and TNF-α levels in patients with pathological type. Conclusion： IL-2, IFN-γ expression in bladder cancer patients are decreased significantly, while TNF-a expression is increased significantly, and the above three indexes of patients are related to clinical stage, but not related to pathological type.
出处
《现代生物医学进展》
CAS
2017年第22期4303-4306,共4页
Progress in Modern Biomedicine
