摘要
目的 对比尿激酶与阿替普酶（rt-PA）通过置管溶栓的方法 治疗急性下肢深静脉血栓形成（ADVT）的临床效果、不良反应和药物费用.方法回顾2010年12月至2015年12月5年间的ADVT患者68例,其中使用尿激酶治疗的37例,使用rt-PA治疗的31例.对比两组的临床疗效、出血并发症、药物费用等.结果 尿激酶组总有效率97.27%,rt-PA组总有效率100%,两组差异无统计学意义（P〉0.05）.两组出血并发症的发生率差异无统计学意义（P〉0.05）.两组药物费用有明显差异（P〈0.05）.结论 尿激酶和rt-PA治疗ADVT均疗效确切,使用安全,尿激酶在药物费用上优势明显.
Objective To investigate the clinical efficacy and adverse reactions of catheter-directed thrombolytic therapy with use of urokinase （UK）and alteplase（rt-PA）in treating acute deep venous thrombosis（ADVT）of lower extremity. Methods During the period form 2010 to 2015,a total of 68 patients with ADVT were admitted to author＆#39;s hospital. Catheter-directed thrombolytic therapy was carried out in all patients by using UK for 37 patients and rt-PA for 31 patients. Additional anticoagulants were employed at the same time. The clinical efficacy,the complication of bleeding,and costs of drugs were observed. Results The total response rate of group UK and group rt-PA were 97.27% and 100% respectively. The difference in the response rate between the two groups was not statistically significant（P〉0.05）. No significant difference was found in the occurrence of bleeding existed between the two groups（P〉0.05）. There was significant difference between the two groups（P〈0.05）. Conclusion Both UK and rt-PA are safe thrombolytics with reliable effect in treating ADVT. UK has obvious advantage in drug costs.
出处
《浙江临床医学》
2017年第8期1426-1427,共2页
Zhejiang Clinical Medical Journal
关键词
经导管
溶栓
血栓形成
Transcatheter
Thrombolysis
Thrombosis
