摘要
肿瘤及其微环境来源的外泌体miRNAs可以促进肿瘤细胞增殖和侵袭运动;通过介导肿瘤细胞与免疫细胞、转移靶器官间的信息交流促进肿瘤细胞定向转移;诱发肿瘤细胞对顺铂和吉西他滨等的耐药;同时针对肿瘤患者血清和唾液中外泌体miRNAs的检测显示出应用于肿瘤诊断和预后判断的潜在重要价值。
Exosomal miRNAs, derived from tumor cells or their microenvironment, could promote the proliferation, migration and invasion of tumor cells; and enhance tumor metastasis via regulating information exchange between tumor cells and immune cells or metastatic target organs ; and induce tumor resistance to cisplatin and gemcitabine; meanwhile, detecting the exosomal miRNAs in the serum and saliva of cancer patients suggested the potential of application in cancer diagnosis and prognosis assessment.
出处
《基础医学与临床》
CSCD
2017年第9期1326-1330,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(81460425)
