摘要
目的:探讨鼠神经生长因子(mNGF)联合高压氧对一氧化碳中毒迟发性脑病(DEACMP)患者血清细胞因子及认知功能的影响。方法:收集本院收治的一氧化碳中毒迟发性脑病患者218例,回顾性分为接受高压氧治疗的对照组100例、接受鼠神经生长因子联合高压氧治疗的观察组118例。对比两组血清中神经损伤指标、炎症介质含量差异,评估其认知功能状态。结果:治疗前,两组患者血清中神经损伤指标、炎症介质含量,MMSE总分及各个维度评分值的差异均无统计学意义(P>0.05)。治疗后,观察组血清中神经损伤指标肌酸激酶-BB(CK-BB)、神经元特异性烯醇化酶(NSE)、S-100β蛋白(S-100β)、乳酸(Lac)的含量低于对照组;血清中炎症介质白介素-6(IL-6)、白介素-10(IL-10)、白介素-18(IL-18)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)的含量低于对照组;MMSE总分及各个维度评分值高于对照组(P<0.05)。结论:mNGF联合高压氧治疗DEACMP,有助于患者神经损伤及全身炎症反应的减轻,认知功能的提升。
Objective：To study the influence of mouse nerve growth factor（mNGF）combined with hyperbaric oxygen on serum cytokines and cognitive function in patients with delayed encephalopathy after carbon monoxide poisoning（DEACMP）.Methods：A total of 218 patients with DEACMP who were treated in our hospital between June 2012 and September 2016 were chosen as research subjects and retrospectively divided into the control group（n=100）who underwent hyperbaric oxygen treatment and the observation group（n=118）who underwent mouse nerve growth factor combined with hyperbaric oxygen treatment.Serum contents of nerve injury indexes and inflammatory mediators were compared between two groups of patients,and cognitive function was assessed.Results：Before treatment,differences in serum levels of nerve injury indexes and inflammatory mediators,total MMSE score and each dimension score were not statistically significant between two groups of patients（P〉0.05）.After treatment,serum contents of nerve injury indexes creatine kinase-BB（CK-BB）,neuron-specific enolase（NSE）,S-100βprotein（S-100β）and lactate（Lac）in observation group were lower than those in control group;serum contents of inflammatory mediators interleukin-6（IL-6）,interleukin-10（IL-10）,interleukin-18（IL-18）,hypersensitive C-reactive protein（hs-CRP）and tumor necrosis factorα（TNF-α）were lower than those in control group;total MMSE score and each dimension score were higher than those of control group（P〈0.05）.Conclusions：mNGF combined with hyperbaric oxygen treatment of DEACMP is helpful to reduce the nerve injury and systemic inflammatory response,and improve the cognitive function.
出处
《海南医学院学报》
CAS
2017年第11期1582-1585,共4页
Journal of Hainan Medical University
基金
新疆医科大学科研创新基金(XJC2012141)~~
关键词
一氧化碳中毒迟发性脑病
鼠神经生长因子
高压氧
认知功能
Delayed encephalopathy after carbon monoxide poisoning
Mouse nerve growth factor
Hyperbaric oxy gen
Cognitive function
