摘要
背景:骨髓间充质干细胞是来源于中胚层的非造血干细胞,主要取材于骨髓,其有着较强的自我更新能力、多向分化能力以及低免疫原性,易于接受外源基因的导入,是近些年研究应用的热点。目的:综述骨髓间充质干细胞在各疾病中的研究与应用进展。方法:由第一作者检索2011至2016年Pub Med数据库(http://www.ncbi.nlm.nih.gov/PubM ed)及中国生物医学文献数据库(http://www.sinomed.ac.cn/zh/),中文检索词为"骨髓间充质干细胞、治疗",英文检索词为"bone marrow mesenchymal stem cells,therapy"。排除重复性研究或Meta分析类文章,共保留其中的49篇文献进行归纳总结。结果与结论:骨髓间充质干细胞在呼吸系统疾病、心血管疾病、泌尿系统疾病、神经系统疾病、肝脏疾病、糖尿病、血液系统疾病、自身免疫性疾病和移植物抗宿主病、运动系统疾病等方面均有了新的研究与应用进展,但其应用仍有致瘤性风险。随着对其深入研究,骨髓间充质干细胞的致瘤等相关问题将逐步得到解决,从而更好地应用于临床。
BACKGROUND： Bone marrow mesenchymal stem cells as non-hematopoietic stem cells from the mesoderm mostly come from the bone marrow, which have a stronger self-renewal ability, multilineage differentiation ability and low immunogenicity and are easy to receive the introduction of foreign genes. Therefore this kind of cells have become the research hotspot in recent years. OBJECTIVE： To summarize the latest clinical application and advancement of bone marrow mesenchymal stem cells in the treatment of various diseases. METHODS： Pub Med（http：//www.ncbi.nlm.nih.gov/Pub Med） and Sino Med（http：//www.sinomed.ac.cn/zh/） databases were searched by the first author using the keywords of ＂bone marrow mesenchymal stem cells, therapy＂ to identify the relevant articles published in English and Chinese, respectively, from 2011 to 2016. After excluding repetitive, irrelevant or Meta-analysis literatures, we enrolled 49 literatures for final analysis. RESULTS AND CONCLUSION： Studies on bone marrow mesenchymal stem cells have achieved new grades in the treatment of respiratory system disease, cardiovascular disease, urinary system disease, nervous system disease, liver disease, diabetes mellitus, hematological system disease, autoimmune disease, graft-versus-host disease, motor system disease, although its application has the risk of oncogenicity. Further investigation on the oncogenicity of bone marrow mesenchymal stem cells will be gradually explored, aiming to a better clinical use of bone marrow mesenchymal stem cells.
出处
《中国组织工程研究》
CAS
北大核心
2017年第21期3400-3406,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金资助项目(81272046)
天津市卫生局攻关课题(14KG121
15KG125)
天津市科学技术委员会课题(15JCYBJC25300)~~
